Quantitative in vivo assessment of intraocular lens calcification: correlation between OCT opacity and straylight measurement
Purpose: - To quantitatively assess intraocular lens (IOL) calcification using anterior segment optical coherence tomography (AS-OCT) and correlate findings with straylight measurements in patients with homogenous IOL calcification. - Setting: - Department of Ophthalmology, Heidelberg University Hos...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 2025
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| In: |
Journal of cataract and refractive surgery
Year: 2025, Volume: 51, Issue: 8 |
| ISSN: | 1873-4502 |
| DOI: | 10.1097/j.jcrs.0000000000001674 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/j.jcrs.0000000000001674 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/jcrs/abstract/2025/08000/quantitative_in_vivo_assessment_of_intraocular.5.aspx 
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| Author Notes: | Mackenbrock Lars H.B. MD, Łabuz Grzegorz PhD, Henningsen Nikola MD, Auffarth Gerd U. MD, FEBO, Khoramnia Ramin MD, FEBO, Yildirim Timur M. MD, MHBA, FEBO |
| Summary: | Purpose: - To quantitatively assess intraocular lens (IOL) calcification using anterior segment optical coherence tomography (AS-OCT) and correlate findings with straylight measurements in patients with homogenous IOL calcification. - Setting: - Department of Ophthalmology, Heidelberg University Hospital, Heidelberg, Germany. - Design: - Prospective, observational clinical study. - Methods: - Healthy patients with homogenous IOL calcification underwent AS-OCT imaging with the ANTERION, with IOL opacity being automatically quantified using a custom image-analysis script. Straylight was assessed using the C-Quant straylight meter. Correlation between IOL opacity and straylight was analyzed using Spearman ρ coefficient. - Results: - 35 eyes of 35 patients (mean age 72.9 ± 7.8 years) were included. Mean IOL opacity was 69.15 ± 13.55 pixel intensity units (PIUs), and mean straylight was 2.24 ± 0.38 log(s). A statistically significant correlation was found between IOL opacity and straylight with ρ = 0.494, P = .003. After the linear regression model was established: straylight = 0.0569 × OCT opacity [log(s)] − 1.69 with R2 = 0.244. Of the 35 eyes, 17 underwent IOL exchange surgery, with a mean IOL opacity of 75.69 ± 7.58 PIU and a mean straylight of 2.33 ± 0.30 log(s). - Conclusions: - AS-OCT can quantitatively assess IOL calcification in vivo, with results correlating significantly with straylight measurements. This technique may serve as a valuable diagnostic tool for evaluating IOL opacification and assist in surgical decision-making, particularly in borderline cases. |
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| Item Description: | Gesehen am 16.01.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1873-4502 |
| DOI: | 10.1097/j.jcrs.0000000000001674 |