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Phenotypes in Brugada syndrome with different genotypes triggered by fever or inflammation using gene-edited iPSCs

Fever or inflammation state may enhance the Brugada syndrome (BrS) phenotype in some but not all patients. However, the underlying mechanism in human cardiomyocytes has not yet been clarified.

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Bibliographic Details
Main Authors: Li, Yingrui (Author) , Rose, Lena (Author) , Prädel, Timo (Author) , Kleinsorge, Mandy (Author) , Fan, Xuehui (Author) , Meng, Zenghui (Author) , Yan, Chen (Author) , Liu, Rui (Author) , Lei, Xinhao (Author) , Zhao, Binyi (Author) , Yang, Guoqiang (Author) , Liao, Zhenxing (Author) , Dinkel, Hendrik (Author) , Busley, Alexandra Viktoria (Author) , Zhong, Rujia (Author) , Zhang, Feng (Author) , Xu, Qiang (Author) , Maywald, Lasse (Author) , Aweimer, Assem (Author) , Huang, Mengying (Author) , Moscu-Gregor, Alexander (Author) , Hamdani, Nazha (Author) , Schneider, Luca (Author) , Zemedi, Yeweynwuha (Author) , Zhazykbayeva, Saltanat (Author) , Hohn, Alyssa (Author) , Yang, Zhen (Author) , Qiao, Lin (Author) , Mügge, Andreas (Author) , Cyganek, Lukas (Author) , Zhou, Xiao-Bo (Author) , Akın, Ibrahim (Author) , El-Battrawy, Ibrahim (Author)
Format: Article (Journal)
Language:English
Published: 01 December 2025
In: Stem cell research & therapy
Year: 2025, Volume: 16, Issue: 1, Pages: 1-16
ISSN:1757-6512
DOI:10.1186/s13287-025-04793-6
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13287-025-04793-6
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Author Notes:Yingrui Li, Lena Rose, Timo Prädel, Mandy Kleinsorge, Xuehui Fan, Zenghui Meng, Chen Yan, Rui Liu, Xinhao Lei, Binyi Zhao, Guoqiang Yang, Zhenxing Liao, Hendrik Dinkel, Alexandra Viktoria Busley, Rujia Zhong, Feng Zhang, Qiang Xu, Lasse Maywald, Assem Aweimer, Mengying Huang, Alexander Moscu-Gregor, Nazha Hamdani, Luca Schneider, Yeweynwuha Zemedi, Saltanat Zhazykbayeva, Alyssa Hohn, Zhen Yang, Lin Qiao, Andreas Mügge, Lukas Cyganek, Xiaobo Zhou, Ibrahim Akin and Ibrahim El-Battrawy
Description
Summary:Fever or inflammation state may enhance the Brugada syndrome (BrS) phenotype in some but not all patients. However, the underlying mechanism in human cardiomyocytes has not yet been clarified.
Item Description:Gesehen am 22.01.2026
Physical Description:Online Resource
ISSN:1757-6512
DOI:10.1186/s13287-025-04793-6

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