The experience of social loss and epigenome-wide DNA methylation
Background - Social loss is associated with mental and physical health problems. Considering known risk and resilience factors, we hypothesized that epigenome-wide DNA methylation (DNAm) would be associated with social loss. - Methods - A total of N = 1865 participants aged 50-75 years with epigenom...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 2026
|
| In: |
Social science & medicine
Year: 2026, Jahrgang: 388, Pages: 1-12 |
| ISSN: | 1873-5347 |
| DOI: | 10.1016/j.socscimed.2025.118718 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.socscimed.2025.118718 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0277953625010494 
|
| Verfasserangaben: | Martin Stoffel, Joshua Stevenson-Hoare, Ben Schöttker, Johanna Hammer, Hermann Brenner, Beate Ditzen |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1950328821 | ||
| 003 | DE-627 | ||
| 005 | 20260127123935.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260127s2026 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.socscimed.2025.118718 |2 doi | |
| 035 | |a (DE-627)1950328821 | ||
| 035 | |a (DE-599)KXP1950328821 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 11 |2 sdnb | ||
| 100 | 1 | |a Stoffel, Martin |d 1988- |e VerfasserIn |0 (DE-588)1121815189 |0 (DE-627)874949610 |0 (DE-576)481000771 |4 aut | |
| 245 | 1 | 4 | |a The experience of social loss and epigenome-wide DNA methylation |c Martin Stoffel, Joshua Stevenson-Hoare, Ben Schöttker, Johanna Hammer, Hermann Brenner, Beate Ditzen |
| 264 | 1 | |c January 2026 | |
| 300 | |b Illustrationen | ||
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar: 25. Oktober 2025, Artikelversion: 15. November 2025 | ||
| 500 | |a Gesehen am 27.01.2026 | ||
| 520 | |a Background - Social loss is associated with mental and physical health problems. Considering known risk and resilience factors, we hypothesized that epigenome-wide DNA methylation (DNAm) would be associated with social loss. - Methods - A total of N = 1865 participants aged 50-75 years with epigenome-wide DNAm measurements obtained from whole blood samples were included. Using cross-sectional data, relationship status (married/divorced/widowed) was expected to predict differences in DNAm between married persons and persons who experienced social loss (divorced/widowhood). Additionally, social factors (i.e., the number of close social relationships and household size), the polygenic risk score for depression, a history of depression, and biological sex were considered as moderators. Predicted differences in DNAm were calculated (Δ-beta values). - Results - Without considering moderators, there was only one differentially methylated position (DMP; cg01450896), comparing married and widowed persons (b = 0.098, q = 0.022; Δ-beta = |0.015|). However, there were a variety of DMPs for the comparison between married persons and those who experienced social loss when the moderators were factored in, especially those indicative of social integration and social connectedness. Δ-beta values varied considerably as a function of changes in the moderators. - Conclusions - Changes in DNAm might contribute to the health-related effects of social loss. In line with his, many of the discovered DMPs were associated with health-related traits in previous studies. However, the reported effects were highly dependent on the moderators assessed and specific to divorce and widowhood. The results could provide a first step toward better understanding and treating individuals who experienced social loss. | ||
| 650 | 4 | |a DNA methylation | |
| 650 | 4 | |a Epigenome-wide analysis | |
| 650 | 4 | |a Polygenic risk score for depression | |
| 650 | 4 | |a Social connectedness | |
| 650 | 4 | |a Social integration | |
| 650 | 4 | |a Social loss | |
| 700 | 1 | |a Stevenson-Hoare, Joshua |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schöttker, Ben |e VerfasserIn |0 (DE-588)138862443 |0 (DE-627)703132423 |0 (DE-576)309375657 |4 aut | |
| 700 | 1 | |a Hammer, Johanna |e VerfasserIn |0 (DE-588)1388082780 |0 (DE-627)1950329526 |4 aut | |
| 700 | 1 | |a Brenner, Hermann |e VerfasserIn |0 (DE-588)1020516445 |0 (DE-627)691247005 |0 (DE-576)360642136 |4 aut | |
| 700 | 1 | |a Ditzen, Beate |d 1975- |e VerfasserIn |0 (DE-588)1064970613 |0 (DE-627)81537545X |0 (DE-576)424658895 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Social science & medicine |d Amsterdam [u.a.] : Elsevier Science, 1967 |g 388(2026) vom: Jan., Artikel-ID 118718, Seite 1-12 |h Online-Ressource |w (DE-627)306710528 |w (DE-600)1500748-0 |w (DE-576)082435901 |x 1873-5347 |7 nnas |a The experience of social loss and epigenome-wide DNA methylation |
| 773 | 1 | 8 | |g volume:388 |g year:2026 |g month:01 |g elocationid:118718 |g pages:1-12 |g extent:12 |a The experience of social loss and epigenome-wide DNA methylation |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.socscimed.2025.118718 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0277953625010494 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20260127 | ||
| 993 | |a Article | ||
| 994 | |a 2026 | ||
| 998 | |g 1064970613 |a Ditzen, Beate |m 1064970613:Ditzen, Beate |d 910000 |d 910600 |e 910000PD1064970613 |e 910600PD1064970613 |k 0/910000/ |k 1/910000/910600/ |p 6 |y j | ||
| 998 | |g 1020516445 |a Brenner, Hermann |m 1020516445:Brenner, Hermann |d 850000 |d 851600 |d 50000 |e 850000PB1020516445 |e 851600PB1020516445 |e 50000PB1020516445 |k 0/850000/ |k 1/850000/851600/ |k 0/50000/ |p 5 | ||
| 998 | |g 1388082780 |a Hammer, Johanna |m 1388082780:Hammer, Johanna |d 910000 |d 950000 |d 950950 |e 910000PH1388082780 |e 950000PH1388082780 |e 950950PH1388082780 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950950/ |p 4 | ||
| 998 | |g 138862443 |a Schöttker, Ben |m 138862443:Schöttker, Ben |d 50000 |e 50000PS138862443 |k 0/50000/ |p 3 | ||
| 998 | |g 1121815189 |a Stoffel, Martin |m 1121815189:Stoffel, Martin |d 100000 |d 100200 |e 100000PS1121815189 |e 100200PS1121815189 |k 0/100000/ |k 1/100000/100200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1950328821 |e 4861726603 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"role":"aut","display":"Stoffel, Martin","family":"Stoffel","given":"Martin"},{"display":"Stevenson-Hoare, Joshua","role":"aut","given":"Joshua","family":"Stevenson-Hoare"},{"role":"aut","display":"Schöttker, Ben","family":"Schöttker","given":"Ben"},{"family":"Hammer","given":"Johanna","role":"aut","display":"Hammer, Johanna"},{"family":"Brenner","given":"Hermann","role":"aut","display":"Brenner, Hermann"},{"role":"aut","display":"Ditzen, Beate","family":"Ditzen","given":"Beate"}],"relHost":[{"note":["Gesehen am 12.04.23"],"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"publisher":"Elsevier Science","dateIssuedKey":"1967","publisherPlace":"Amsterdam [u.a.]","dateIssuedDisp":"1967-"}],"disp":"The experience of social loss and epigenome-wide DNA methylationSocial science & medicine","id":{"issn":["1873-5347"],"zdb":["1500748-0"],"eki":["306710528"]},"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["16.1982 -"],"part":{"extent":"12","pages":"1-12","volume":"388","year":"2026","text":"388(2026) vom: Jan., Artikel-ID 118718, Seite 1-12"},"title":[{"title":"Social science & medicine","title_sort":"Social science & medicine"}],"language":["eng"],"titleAlt":[{"title":"Social science and medicine"}],"recId":"306710528"}],"note":["Online verfügbar: 25. Oktober 2025, Artikelversion: 15. November 2025","Gesehen am 27.01.2026"],"origin":[{"dateIssuedKey":"2026","dateIssuedDisp":"January 2026"}],"physDesc":[{"extent":"12 S.","noteIll":"Illustrationen"}],"id":{"eki":["1950328821"],"doi":["10.1016/j.socscimed.2025.118718"]},"title":[{"title_sort":"experience of social loss and epigenome-wide DNA methylation","title":"The experience of social loss and epigenome-wide DNA methylation"}],"language":["eng"],"recId":"1950328821","name":{"displayForm":["Martin Stoffel, Joshua Stevenson-Hoare, Ben Schöttker, Johanna Hammer, Hermann Brenner, Beate Ditzen"]}} | ||
| SRT | |a STOFFELMAREXPERIENCE2026 | ||