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A case of fatal intoxication with the novel synthetic opioid N-pyrrolidino protonitazene

The presence of 2-benzylbenzimidazole-derived opioids (nitazenes) in the drug market is steadily increasing. These often highly potent synthetic opioids can cause severe, potentially fatal effects. This case report presents a fatal intoxication following the vaping of the novel synthetic opioid N-py...

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Bibliographic Details
Main Authors: Wrbas, Sophia (Author) , Sundermann, Tom R. (Author) , Auwärter, Volker (Author) , Huppertz, Laura M. (Author)
Format: Article (Journal)
Language:English
Published: 18 October 2025
In: International journal of legal medicine
Year: 2025, Pages: 1-6
ISSN:1437-1596
DOI:10.1007/s00414-025-03618-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00414-025-03618-8
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00414-025-03618-8?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate
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Author Notes:Sophia Wrbas, Tom R. Sundermann, Volker Auwärter, Laura M. Huppertz
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Summary:The presence of 2-benzylbenzimidazole-derived opioids (nitazenes) in the drug market is steadily increasing. These often highly potent synthetic opioids can cause severe, potentially fatal effects. This case report presents a fatal intoxication following the vaping of the novel synthetic opioid N-pyrrolidino protonitazene (protonitazepyne), detected in serum obtained 10 h postmortem and in multiple specimens collected at autopsy three days after death.
Item Description:Gesehen am 30.01.2026
Physical Description:Online Resource
ISSN:1437-1596
DOI:10.1007/s00414-025-03618-8

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