Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity
Plasticity is a hallmark of aggressive tumors, including glioblastoma (GBM), enabling tumor cells and the tumor microenvironment (TME) to adapt to diverse niches and evade treatment. Here, we discuss how innate and adaptive immune players cooperate in time and space to create an immunosuppressive TM...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 2026
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| In: |
Nature cancer
Year: 2026, Volume: 7, Pages: 29-42 |
| ISSN: | 2662-1347 |
| DOI: | 10.1038/s43018-025-01097-9 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s43018-025-01097-9 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s43018-025-01097-9 
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| Author Notes: | Pilar M. Moreno-Sanchez, Mahsa Rezaeipour, Else Marit Inderberg, Michael Platten & Anna Golebiewska |
| Summary: | Plasticity is a hallmark of aggressive tumors, including glioblastoma (GBM), enabling tumor cells and the tumor microenvironment (TME) to adapt to diverse niches and evade treatment. Here, we discuss how innate and adaptive immune players cooperate in time and space to create an immunosuppressive TME that supports GBM growth and confers resistance to conventional treatments and immunotherapies. We highlight how therapeutic interventions reshape the TME, underscoring the need for targeted approaches to overcome resistance. We introduce the concepts of local TME priming and TME rewiring as necessary foundations for achieving more effective and durable clinical responses in the future. |
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| Item Description: | Online veröffentlicht: 8. Januar 2026 Gesehen am 10.02.2026 |
| Physical Description: | Online Resource |
| ISSN: | 2662-1347 |
| DOI: | 10.1038/s43018-025-01097-9 |