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Deletion of the angiopoietin receptor Tie2 enhances proliferation and sprouting of cardiac endothelial cells

Endothelial cells (ECs) of the heart proliferate and form new vessels in response to vascular endothelial growth factor (VEGF), but VEGF has not benefited the therapy of cardiac ischemia because of its side effects. Here, we explored if deletion of the vascular steady-state homeostasis maintaining T...

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Bibliographische Detailangaben
Hauptverfasser: Anisimov, Andrey (VerfasserIn) , Lackman, Madeleine H. (VerfasserIn) , Augustin, Hellmut (VerfasserIn) , Mervaala, Eero (VerfasserIn) , Alitalo, Kari (VerfasserIn) , Karaman, Sinem (VerfasserIn)
Dokumenttyp: Article (Journal) Editorial
Sprache:Englisch
Veröffentlicht: 21 January 2026
In: Angiogenesis
Year: 2026, Jahrgang: 29, Heft: 2, Pages: 1-9
ISSN:1573-7209
DOI:10.1007/s10456-025-10028-2
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s10456-025-10028-2
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s10456-025-10028-2
Volltext
Verfasserangaben:Andrey Anisimov, Madeleine H. Lackman, Hellmut G. Augustin, Eero Mervaala, Kari Alitalo, Sinem Karaman
Beschreibung
Zusammenfassung:Endothelial cells (ECs) of the heart proliferate and form new vessels in response to vascular endothelial growth factor (VEGF), but VEGF has not benefited the therapy of cardiac ischemia because of its side effects. Here, we explored if deletion of the vascular steady-state homeostasis maintaining Tie1 and Tie2 receptor tyrosine kinases affects the proliferation and sprouting of cardiac ECs.
Beschreibung:Gesehen am 12.02.2026
Beschreibung:Online Resource
ISSN:1573-7209
DOI:10.1007/s10456-025-10028-2

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