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Optimizing whole-body MRI for early cancer detection in Li-Fraumeni syndrome: a prospective bicentric study

Annual whole-body MRI (WB-MRI) is recommended for early cancer detection in individuals with Li-Fraumeni syndrome (LFS). However, there is no agreement on a standardized MRI protocol. This study evaluated the diagnostic performance of different MRI sequences to suggest an optimized protocol for LFS...

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Main Authors: Keymling, Myriam (Author) , Kurz, Felix T. (Author) , Kuder, Tristan Anselm (Author) , Bickelhaupt, Sebastian (Author) , Hielscher, Thomas (Author) , Hog, Robert (Author) , Mokry, Theresa (Author) , Moher Alsady, Tawfik (Author) , Schott, Sarah (Author) , Kratz, Christian Peter (Author) , Renz, Diane Miriam Esther (Author) , Schlemmer, Heinz-Peter (Author)
Format: Article (Journal)
Language:English
Published: 21 October 2025
In: European radiology
Year: 2025, Pages: 1-12
ISSN:1432-1084
DOI:10.1007/s00330-025-11880-y
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00330-025-11880-y
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00330-025-11880-y?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate
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Author Notes:Myriam Margareta Keymling, Felix Tobias Kurz, Tristan Anselm Kuder, Sebastian Bickelhaupt, Thomas Hielscher, Robert Hog, Theresa Mokry, Tawfik Moher Alsady, Sarah Schott, Christian Kratz, Diane Miriam Renz and Heinz-Peter Schlemmer
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Summary:Annual whole-body MRI (WB-MRI) is recommended for early cancer detection in individuals with Li-Fraumeni syndrome (LFS). However, there is no agreement on a standardized MRI protocol. This study evaluated the diagnostic performance of different MRI sequences to suggest an optimized protocol for LFS surveillance.
Item Description:Gesehen am 13.02.2026
Physical Description:Online Resource
ISSN:1432-1084
DOI:10.1007/s00330-025-11880-y

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