Validation of novel low-dose CT methods for quantifying bone marrow in the appendicular skeleton of patients with multiple myeloma: initial results from the [¹⁸F]FDG PET/CT sub-study of the Phase 3 GMMG-HD7 Trial

The clinical significance of medullary abnormalities in the appendicular skeleton detected by computed tomography (CT) in patients with multiple myeloma (MM) remains incompletely elucidated. This study aims to validate novel low-dose CT-based methods for quantifying myeloma bone marrow (BM) volume i...

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Main Authors:	Sachpekidis, Christos (Author) , Hajiyianni, Marina (Author) , Grözinger, Martin (Author) , Piller, Maja (Author) , Kopp-Schneider, Annette (Author) , Mai, Elias K. (Author) , John, Lukas (Author) , Sauer, Sandra (Author) , Weinhold, Niels (Author) , Menis, Ekaterina (Author) , Enqvist, Olof (Author) , Raab, Marc-Steffen (Author) , Jauch, Anna (Author) , Edenbrandt, Lars (Author) , Hundemer, Michael (Author) , Brobeil, Alexander (Author) , Jende, Johann (Author) , Schlemmer, Heinz-Peter (Author) , Delorme, Stefan (Author) , Goldschmidt, Hartmut (Author) , Dimitrakopoulou-Strauss, Antonia (Author)
Format:	Article (Journal)
Language:	English
Published:	1 October 2025
In:	European journal of nuclear medicine and molecular imaging Year: 2026, Volume: 53, Issue: 3, Pages: 1509-1520
ISSN:	1619-7089
DOI:	10.1007/s00259-025-07599-z
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00259-025-07599-z
Author Notes:	Christos Sachpekidis, Marina Hajiyianni, Martin Grözinger, Maja Piller, Annette Kopp-Schneider, Elias K. Mai, Lukas John, Sandra Sauer, Niels Weinhold, Ekaterina Menis, Olof Enqvist, Marc S. Raab, Anna Jauch, Lars Edenbrandt, Michael Hundemer, Alexander Brobeil, Johann Jende, Heinz-Peter Schlemmer, Stefan Delorme, Hartmut Goldschmidt, Antonia Dimitrakopoulou-Strauss