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The Lucerne Toolbox 3: digital health and artificial intelligence to optimise the patient journey in early breast cancer : a multidisciplinary consensus : policy review

The Lucerne Toolbox 3 initiative addresses the pressing need for evidence-based integration of digital health and artificial intelligence (AI) technologies in early breast cancer care. The multidisciplinary consortium identified and prioritised 15 crucial medical knowledge gaps across the patient jo...

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Main Authors: Pfob, André (Author) , Pinker, Katja (Author) , Vaz-Luis, Ines (Author) , Di Meglio, Antonio (Author) , Cardoso, Maria João (Author) , Curigliano, Giuseppe (Author) , Gentilini, Oreste Davide (Author) , Gruber, Günther (Author) , Hauser, Nik (Author) , Heil, Jörg (Author) , Kaidar-Person, Orit (Author) , Knauer, Michael (Author) , Lee, Han-Byoel (Author) , Lee, Sae Byul (Author) , Loi, Sherene (Author) , Mannhart, Meinrad (Author) , Mastora, Stella (Author) , Meattini, Icro (Author) , Di Micco, Rosa (Author) , Noske, Aurelia (Author) , Peccatori, Fedro Alessandro (Author) , Poulakaki, Fiorita (Author) , Reinisch, Mattea (Author) , Rubio, Isabel T (Author) , Swanton, Charlie (Author) , Tausch, Christoph (Author) , Vrancken Peeters, Marie-Jeanne (Author) , Yu, Jong Han (Author) , Weber, Walter Paul (Author) , Zerbe, Norman (Author) , Poortmans, Philip (Author) , Denkert, Carsten (Author) , Mann, Ritse (Author) , Delaloge, Suzette (Author) , Dubsky, Peter (Author)
Format: Article (Journal)
Language:English
Published: December 2025
In: The lancet. Oncology
Year: 2025, Volume: 26, Issue: 12, Pages: 694-706
ISSN:1474-5488
DOI:10.1016/S1470-2045(25)00463-2
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S1470-2045(25)00463-2
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1470204525004632
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Author Notes:André Pfob, Katja Pinker, Ines Vaz-Luis, Antonio Di Meglio, Maria João Cardoso, Giuseppe Curigliano, Oreste Davide Gentilini, Günther Gruber, Nik Hauser, Jörg Heil, Orit Kaidar-Person, Michael Knauer, Han-Byoel Lee, Sae Byul Lee, Sherene Loi, Meinrad Mannhart, Stella Mastora, Icro Meattini, Rosa Di Micco, Aurelia Noske, Fedro Alessandro Peccatori, Fiorita Poulakaki, Mattea Reinisch, Isabel T Rubio, Charlie Swanton, Christoph Tausch, Marie-Jeanne Vrancken Peeters, Jong Han Yu, Walter Paul Weber, Norman Zerbe, Philip Poortmans, Carsten Denkert, Ritse Mann, Suzette Delaloge, Peter Dubsky, for the Toolbox 3 Consortium
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Summary:The Lucerne Toolbox 3 initiative addresses the pressing need for evidence-based integration of digital health and artificial intelligence (AI) technologies in early breast cancer care. The multidisciplinary consortium identified and prioritised 15 crucial medical knowledge gaps across the patient journey, from diagnosis to treatment and survivorship, using a modified Delphi consensus process with 112 unique members from 27 countries and 16 medical societies, trial groups, and patient organisations. The knowledge gaps include AI-based mammography screening, personalised screening strategies, digital knowledge databases, AI-driven treatment optimisation, and digitally delivered monitoring and supportive care. The consortium developed 13 trial designs in the Population, Intervention, Comparison, and Outcome format to address these gaps, achieving consensus or majority vote in 98% of statements. The recommendations emphasise precision medicine, patient-centred care, and interdisciplinary collaboration to improve outcomes, efficiency, and equity in breast cancer care. By presenting a roadmap for actionable trials, Lucerne Toolbox 3 sets a foundation for advancing digital health in breast cancer care.
Item Description:Mitglieder des Toolbox 3 Consortium: Alexandra Athanasiou, Marianne Aznar, Thomas Bachelot, Zsuzsanna Bago-Horvath, Maggie Banys-Paluchowski, Sophia Belouka, Almir Bitencourt, Liesbeth Boersma, Kimberly Bowles, Roswitha Britz, Samantha Brunsden, Carmela Caballero, Julia Camps-Herrero, Giuseppe F Catanuto, Effimia Chatzinikolaou, Charlotte Coles, Stefanie Corradini, Terri Coutee, Jana de Boniface, Antonio Di Meglio, Joachim Diebold, Susanne Dieroff Hay, Nina Ditsch, David Dodwell, Ian Ellis, Sarah Eskreis-Winkler, Pierfrancesco Franco, Maria Alice Franzoi, Helen Frazer, Thomas frederic-moreau, Michael Fuchsjäger, Dorota Gabryś, Ursula Ganz-Blättler, Maria Luisa Gasparri, Mami Iima, Eva Karamitopoulou, Maria Katapodi, Marietta Kirchner, Antigoni Kretsi, Randi Krogsgaard, David Krug, Thorsten Kuehn, Christiane Kuhl, Kristina Lång, Kyung-Hun Lee, Sae Byul Lee, Hee Jin Lee, Vincenzo L'Imperio, Mairead MacKenzie, Maja Vestmø Maraldo, Stuart A McIntosh, Ingvil Mjaaland, Angel Montero, Linda Moy, Rosine Mucklow, Sudeshen Naidoo, Anu Niemi, Federica Pediconi, Frederique Penault-Llorca, Marlen Pfeiffer, André Pfob, Katja Pinker, Niklas Prenissl, Nina Radosevic-Robin, Duvern Ramiah, Ivica Ratosa, Tilman Rau, Evangelia Razis, Peter Regitnig, Nicola Rocco, Patrizia Sager, Pedro F Saint-Maurice, Anja Sander, Francesco Sardanelli, Elisabet Schesny, Simone Schiaffino, Alexander Schipf, Maximilian Schuessler, Jane Shaw, Davide Soldato, Stamatis Stamatelopoulos, Petra Steyerova, Philipp Ströbel, Laura Testa, Thiemo JA van Nijnatten, Ines Vaz, Ines Vaz Luis, Sara E Vazquez-Manjarrez, Maria Vidal, Jose Volders, Markus Wallwiener, Lynda Wyld, Nicholas Zdenkowski
Online verfügbar: 24. November 2025, Artikelversion: 24. November 2025
Gesehen am 17.02.2026
Physical Description:Online Resource
ISSN:1474-5488
DOI:10.1016/S1470-2045(25)00463-2

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