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Early detection of cell death using transmembrane water exchange magnetic resonance imaging

Cell death plays a key role in cancer progression and treatment. After its onset, cell membrane integrity is often compromised. Here, it is shown in cells, animals and humans that the transmembrane water exchange rate, measured using magnetic resonance filter-exchange spectroscopy (FEXSY) or imaging...

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Main Authors: Kaika, Athanasia (Author) , Nagel, Luca (Author) , Höckendorf, Ulrike (Author) , Xie, Bangwen (Author) , Topping, Geoffrey J. (Author) , Schillmaier, Mathias (Author) , Beer, Irina (Author) , van Heijster, Frits H. A. (Author) , Rauch, Julian (Author) , Kuder, Tristan Anselm (Author) , Sühnel, Sandra (Author) , Erber, Bernd (Author) , Lohrmann, Christian (Author) , Ballke, Simone (Author) , Metzler, Thomas (Author) , Steiger, Katja (Author) , Jost, Philipp J. (Author) , Ivleva, Natalia P. (Author) , Paprottka, Philipp (Author) , Nadjiri, Jonathan (Author) , Brindle, Kevin M. (Author) , Weber, Wolfgang A. (Author) , Schilling, Franz (Author)
Format: Article (Journal)
Language:English
Published: 2025
In: Advanced science
Year: 2025, Pages: 1-14
ISSN:2198-3844
DOI:10.1002/advs.202513317
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/advs.202513317
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.202513317
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Author Notes:Athanasia Kaika, Luca Nagel, Ulrike Höckendorf, Bangwen Xie, Geoffrey J. Topping, Mathias Schillmaier, Irina Beer, Frits H.A. van Heijster, Julian Rauch, Tristan A. Kuder, Sandra Sühnel, Bernd Erber, Christian Lohrmann, Simone Ballke, Thomas Metzler, Katja Steiger, Philipp J. Jost, Natalia P. Ivleva, Philipp Paprottka, Jonathan Nadjiri, Kevin M. Brindle, Wolfgang A. Weber, and Franz Schilling
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Summary:Cell death plays a key role in cancer progression and treatment. After its onset, cell membrane integrity is often compromised. Here, it is shown in cells, animals and humans that the transmembrane water exchange rate, measured using magnetic resonance filter-exchange spectroscopy (FEXSY) or imaging (FEXI), and quantified by the apparent exchange rate (AXR), is an early biomarker of cell death. AXR measurements detect the onset of cell death in vivo earlier than diffusion-weighted MRI (DWI) and in vitro with similar sensitivity as flow cytometry. 13C magnetic resonance imaging (MRI) measurements of the malate/fumarate ratio (MFR), following injection of hyperpolarized [1,4-13C2]fumarate, in tumors displaying diffuse necrosis, are correlated with AXR. AXR detects early treatment response in colorectal and lymphoma tumor models while the apparent diffusion coefficient (ADC) measured by DWI remains unchanged. AXR measurements in human uterine fibroids show sensitivity to post-treatment changes soon after embolization, demonstrating clinical translatability of the method.
Item Description:Zuerst veröffentlicht: 17. Dezember 2025
Gesehen am 18.02.2026
Physical Description:Online Resource
ISSN:2198-3844
DOI:10.1002/advs.202513317

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