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Genome-wide analysis defines genetic determinants of MPN subtypes and identifies a sex-specific association at CDH22/CD40

To identify genetic variants that influence myeloproliferative neoplasm (MPN) phenotypes, we undertook a 2-stage patient-only genome-wide association study. MPN subtypes (essential thrombocythemia [ET]; polycythemia vera [PV]) were compared with each other to healthy controls and stratified analyses...

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Hauptverfasser: Tapper, William (VerfasserIn) , Dawoud, Ahmed A. Z. (VerfasserIn) , Score, Joannah (VerfasserIn) , Chase, Andrew J. (VerfasserIn) , Baxter, E. Joanna (VerfasserIn) , Ewing, Joanne (VerfasserIn) , Wallis, Louise (VerfasserIn) , Guglielmelli, Paola (VerfasserIn) , Colomer, Dolors (VerfasserIn) , Bellosillo, Beatriz (VerfasserIn) , Gomez, Montse (VerfasserIn) , Hernández-Boluda, Juan Carlos (VerfasserIn) , Besses, Carlos (VerfasserIn) , Cervantes, Francisco (VerfasserIn) , Koschmieder, Steffen (VerfasserIn) , Green, Anthony R. (VerfasserIn) , Reiter, Andreas (VerfasserIn) , Vannucchi, Alessandro (VerfasserIn) , Harrison, Claire (VerfasserIn) , Cross, Nicholas C. P. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: December 25, 2025
In: Blood
Year: 2025, Jahrgang: 146, Heft: 26, Pages: 3228-3233
ISSN:1528-0020
DOI:10.1182/blood.2025028489
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood.2025028489
Volltext
Verfasserangaben:William J. Tapper, Ahmed A.Z. Dawoud, Joannah Score, Andrew J. Chase, E. Joanna Baxter, Joanne Ewing, Louise Wallis, Paola Guglielmelli, Dolors Colomer, Beatriz Bellosillo, Montse Gomez, Juan Carlos Hernández-Boluda, Carlos Besses, Francisco Cervantes, Steffen Koschmieder, Anthony R. Green, Andreas Reiter, Alessandro Vannucchi, Claire Harrison, Nicholas C.P. Cross
Beschreibung
Zusammenfassung:To identify genetic variants that influence myeloproliferative neoplasm (MPN) phenotypes, we undertook a 2-stage patient-only genome-wide association study. MPN subtypes (essential thrombocythemia [ET]; polycythemia vera [PV]) were compared with each other to healthy controls and stratified analyses was performed for chromosome 9p aberrations, JAK2 V617F mutation burden, and sex. The ET vs PV analysis identified known associations: (1) at HBS1L-MYB that increased ET risk (Pmeta = 7.93 × 10-6, odds ratio [OR] = 1.28) and reduced PV risk (Pmeta = 9.43 × 10-5, OR = 0.81) and (2) at GFI1B-GTF3C5 that predisposed to PV only (Pmeta = 1.43 × 10-9, OR = 1.38). Two further linked intronic variants, rs2425786 and rs2425788, at CDH22/CD40 were significant in females only (Pmeta = 2.67 × 10-8), with predisposition to PV (Pmeta = .0006, OR = 1.3) and reduction of ET risk (Pmeta = 7.82 × 10-5, OR = 0.75). A polygenic risk score consisting of 48 variants from 31 loci demonstrated moderate discriminative performance for ET and PV (area under the curve [AUC] = 0.718) and was improved by optimization for disease subtype (AUCET = 0.724 and AUCPV = 0.755). Overall, our results reveal that multiple germline variants influence MPN phenotype, with HBS1L-MYB and a novel sex-specific association with CDH22/CD40 being the strongest determinants.
Beschreibung:Gesehen am 19.02.2026
Beschreibung:Online Resource
ISSN:1528-0020
DOI:10.1182/blood.2025028489

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