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A printable, unimolecular, core-shell polymer bottlebrush-based signal transducer using solvatochromatic reporting

The combination of stimuli-responsiveness, colloidal stability and tolerance to changes in concentration and ionic strength into a functional nanoparticle system is challenging. Self-assembled polymer materials remain susceptible to environmental changes, which in turn limit their application potent...

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Hauptverfasser: Zhang, Chenyou (VerfasserIn) , Catt, Samantha (VerfasserIn) , Hawtrey, Tom (VerfasserIn) , Zeng, Ping (VerfasserIn) , Zeng, Haoxiang (VerfasserIn) , Kerai, Simran D. (VerfasserIn) , Cheng, Yen Theng (VerfasserIn) , Hopp, Moritz Philipp (VerfasserIn) , Yang, Qinqin (VerfasserIn) , New, Elizabeth J. (VerfasserIn) , Blasco, Eva (VerfasserIn) , Müllner, Markus (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2026
In: Chemical science
Year: 2026, Jahrgang: 17, Heft: 1, Pages: 475-481
ISSN:2041-6539
DOI:10.1039/D5SC07029E
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1039/D5SC07029E
Verlag, kostenfrei, Volltext: https://pubs.rsc.org/en/content/articlelanding/2026/sc/d5sc07029e
Volltext
Verfasserangaben:Chenyou Zhang, Samantha O. Catt, Tom Hawtrey, Ping Zeng, Haoxiang Zeng, Simran D. Kerai, Yen Theng Cheng, Moritz P. Hopp, Qinqin Yang, Elizabeth J. New, Eva Blasco and Markus Müllner
Beschreibung
Zusammenfassung:The combination of stimuli-responsiveness, colloidal stability and tolerance to changes in concentration and ionic strength into a functional nanoparticle system is challenging. Self-assembled polymer materials remain susceptible to environmental changes, which in turn limit their application potential. Unimolecular architectures like bottlebrush polymers offer enhanced stability and functional compartmentalisation within a single macromolecule. Here, we report the synthesis of a pH-responsive molecular polymer bottlebrush (MPB) featuring a poly[(diisopropylamino)ethyl methacrylate] (PDPAEMA) core, a hydrophilic poly[poly(ethylene glycol) methyl ether methacrylate] (PPEGMA) shell, and naphthalimide-based solvatochromic fluorophores embedded within its core. The PDPAEMA segment imparts pH sensitivity, while the PEGMA shell improves colloidal stability and biocompatibility. The solvatochromic dyes report environmental changes by responding to polarity shifts in the polymer architecture and polymer networks. Our proof-of-concept study promises future application of such unimolecular constructs as nanoscale pH sensors for biomedicine or as functional additives for 3D printing capable of reporting environmental changes within a printed network or (hydro)gel.
Beschreibung:Zuerst veröffentlicht: 18 Nov 2025
Gesehen am 23.02.2026
Beschreibung:Online Resource
ISSN:2041-6539
DOI:10.1039/D5SC07029E

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