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Roles of catecholamines and inflammation in endothelial dysfunction: a study using Takotsubo syndrome patient-specific hiPSC-ECs

Takotsubo syndrome (TTS), also known as stress-induced cardiomyopathy, is characterized by transient left ventricular dysfunction often triggered by emotional or physical stress. Catecholamines are believed to play a pivotal role in the pathogenesis of TTS, including endothelial dysfunction. This st...

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Main Authors: Yang, Guoqiang (Author) , Zhong, Luyi (Author) , Wang, Jiayue (Author) , Yang, Chenyu (Author) , Cyganek, Lukas (Author) , Hamdani, Nazha (Author) , Zhou, Xiao-Bo (Author) , Fan, Xuehui (Author) , El-Battrawy, Ibrahim (Author) , Akın, Ibrahim (Author)
Format: Article (Journal)
Language:English
Published: 06 February 2026
In: Stem cell reviews and reports

ISSN:2629-3277
DOI:10.1007/s12015-026-11059-y
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s12015-026-11059-y
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Author Notes:Guoqiang Yang, Luyi Zhong, Jiayue Wang, Chenyu Yang, Lukas Cyganek, Nazha Hamdani, Xiaobo Zhou, Xuehui Fan, Ibrahim El-Battrawy, Ibrahim Akin
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Summary:Takotsubo syndrome (TTS), also known as stress-induced cardiomyopathy, is characterized by transient left ventricular dysfunction often triggered by emotional or physical stress. Catecholamines are believed to play a pivotal role in the pathogenesis of TTS, including endothelial dysfunction. This study aimed to elucidate the catecholamine-induced endothelial dysfunction using patient-specific induced pluripotent stem cell-derived endothelial cells (hiPSC-ECs) from TTS patients.
Item Description:Gesehen am 26.02.2026
Physical Description:Online Resource
ISSN:2629-3277
DOI:10.1007/s12015-026-11059-y

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