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Targeted therapy in patients with genetic tumor syndromes

Significant progress in comprehensive molecular diagnostics and targeted therapies for advanced malignancies has, in part, led to substantial improvements in patient outcomes. Nevertheless, comprehensive genomic profiling necessitates interdisciplinary discussion of potential clinical recommendation...

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Bibliographische Detailangaben
Hauptverfasser: Jahn, Arne (VerfasserIn) , Heining, Christoph (VerfasserIn) , Fröhling, Stefan (VerfasserIn) , Glimm, Hanno (VerfasserIn) , Schröck, Evelin (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 8. November 2025
In: Medizinische Genetik
Year: 2025, Jahrgang: 37, Heft: 4, Pages: 321-335
ISSN:1863-5490
DOI:10.1515/medgen-2025-2045
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1515/medgen-2025-2045
Verlag, kostenfrei, Volltext: https://www.degruyterbrill.com/document/doi/10.1515/medgen-2025-2045/html
Volltext
Verfasserangaben:Arne Jahn, Christoph Heining, Stefan Fröhling, Hanno Glimm, Evelin Schröck

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520 |a Significant progress in comprehensive molecular diagnostics and targeted therapies for advanced malignancies has, in part, led to substantial improvements in patient outcomes. Nevertheless, comprehensive genomic profiling necessitates interdisciplinary discussion of potential clinical recommendations within interdisciplinary molecular tumor boards. (Likely) pathogenic germline variants (PGVs) typically warrant genetic counseling for patients and, where appropriate, their relatives. Concurrently, the rapidly expanding availability of targeted therapies introduces new therapeutic implications based on germline alterations that must be integrated into clinical decision-making. Moreover, the identification of PGVs may not only inform therapy in patients with manifest malignancy but also offer opportunities for targeted chemoprevention. 
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