Buchumschlag

Laparoscopic resection rectopexy versus Delorme’s procedure in full-thickness rectal prolapse: a randomized multicenter trial (DELORES-RCT) : randomized controlled trial

Objective:  The DELORES trial investigated whether laparoscopic resection rectopexy (LRR) is superior to Delorme’s procedure (DP) in full-thickness rectal prolapse. Background: Multiple perineal and transabdominal procedures are current practice for rectal prolapse surgery. Evidence from adequately...

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Bibliographische Detailangaben
Hauptverfasser: Herrle, Florian (VerfasserIn) , Şandra-Petrescu, Flavius Ionuţ (VerfasserIn) , Rothenhoefer, Simone (VerfasserIn) , Hardt, Julia (VerfasserIn) , Seyfried, Steffen (VerfasserIn) , Joos, Andreas (VerfasserIn) , Herold, Alexander (VerfasserIn) , Bussen, Dieter (VerfasserIn) , Post, Stefan (VerfasserIn) , Brunner, Marion (VerfasserIn) , Fürst, Alois (VerfasserIn) , De Santo, Gianluca (VerfasserIn) , Siegel, Robert (VerfasserIn) , Strik, Martin (VerfasserIn) , Sprossmann, Michael (VerfasserIn) , Berg, Eugen (VerfasserIn) , Ommer, Andreas (VerfasserIn) , Walz, Martin K. (VerfasserIn) , Benecke, Claudia (VerfasserIn) , Bouchard, Ralf (VerfasserIn) , Keck, Tobias (VerfasserIn) , Weimann, Dirk (VerfasserIn) , Schiedeck, Thomas (VerfasserIn) , Demartines, Nicolas (VerfasserIn) , Hahnloser, Dieter (VerfasserIn) , Sander, Anja (VerfasserIn) , Sauer, Lukas D. (VerfasserIn) , Klose, Christina (VerfasserIn) , Kieser, Meinhard (VerfasserIn) , Diener, Markus (VerfasserIn) , Klotz, Rosa (VerfasserIn) , Reißfelder, Christoph (VerfasserIn) , Kienle, Peter (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: December 2025
In: Annals of surgery
Year: 2025, Jahrgang: 282, Heft: 6, Pages: 939-945
ISSN:1528-1140
DOI:10.1097/SLA.0000000000006708
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1097/SLA.0000000000006708
Verlag, kostenfrei, Volltext: https://journals.lww.com/annalsofsurgery/fulltext/2025/12000/laparoscopic_resection_rectopexy_versus_delorme_s.12.aspx
Volltext
Verfasserangaben:Florian Herrle, MD, Flavius Sandra-Petrescu, MD, Simone Rothenhoefer, MD, Julia Hardt, MD, Steffen Seyfried, MD, Andreas Joos, MD, Alexander Herold, MD, Dieter Bussen, MD, Stefan Post, MD, Marion Brunner, MD, Alois Fürst, MD, Gianluca De Santo, MD, Robert Siegel, MD, Martin Strik, MD, Michael Sprossmann, MD, Eugen Berg, MD, Andreas Ommer, MD, Martin K. Walz, MD, Claudia Benecke, MD, Ralf Bouchard, MD, Tobias Keck, MD, Dirk Weimann, MD, Thomas Schiedeck, MD, Nicolas Demartines, MD, Dieter Hahnloser, MD, Anja Sander, PhD, Lukas D. Sauer, Christina Klose, Meinhard Kieser, PhD, Markus Diener, MD, Rosa Klotz, MD, Christoph Reissfelder, MD, and Peter Kienle, MD
Beschreibung
Zusammenfassung:Objective:  The DELORES trial investigated whether laparoscopic resection rectopexy (LRR) is superior to Delorme’s procedure (DP) in full-thickness rectal prolapse. Background: Multiple perineal and transabdominal procedures are current practice for rectal prolapse surgery. Evidence from adequately designed randomized studies addressing the question of which of these procedures are superior in terms of recurrence and bowel function is lacking. Methods: DELORES was a randomized, observer-blinded, expertise-based multicenter trial. Patients with full-thickness rectal prolapse were eligible. The primary outcome was time to recurrence of full-thickness rectal prolapse within 24 months after primary surgery. The main secondary endpoints were morbidity, hospital stay, quality of life, constipation, and fecal incontinence (DRKS00000482). Results: A total of 358 patients were screened between September 2010 and January 2016. Based on screening, 70 patients were randomized and 65 were included in the analysis (33 LRR and 32 DP procedures). The median follow-up was 23.9 months. Analysis of the primary outcome showed that LRR was superior to DP (P=0.0012). During the 24-month follow-up, 8.2% of patients in the LRR group had a full-thickness prolapse recurrence versus 42.8% in the DP group. The median time to recurrence was 17.8 months for LRR and 8.2 months for DP. The median duration of surgery was 212 min (LRR) versus 77 min (DP). Overall postoperative morbidity was low. The reoperation rate was higher for DP (0% LRR vs. 33.3% DP). Quality of life (FIQL) and incontinence scores (Wexner) were more favorable for LRR at 24-month follow-up. Conclusions: LRR is superior to DP in terms of recurrence and has favorable functional results.
Beschreibung:Gesehen am 03.03.2026
Beschreibung:Online Resource
ISSN:1528-1140
DOI:10.1097/SLA.0000000000006708

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