Deciphering neuron-tumor networks with rabies virus-based retrograde tracing
Glioblastomas are highly invasive and therapy-resistant brain tumors that colonize the entire brain.1 Beyond mechanisms inherent to tumors themselves, the discovery that tumor cells form unidirectional synaptic connections with neurons, particularly glutamatergic neurons, has transformed our underst...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 2025
|
| In: |
Neuro-Oncology
Year: 2025, Volume: 27, Issue: 6, Pages: 1405-1406 |
| ISSN: | 1523-5866 |
| DOI: | 10.1093/neuonc/noaf066 |
| Online Access: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1093/neuonc/noaf066 Verlag, kostenfrei, Volltext: https://academic.oup.com/neuro-oncology/article/27/6/1405/8150883 
|
| Author Notes: | Ekin Reyhan, Svenja K. Tetzlaff, and Varun Venkataramani |
| Summary: | Glioblastomas are highly invasive and therapy-resistant brain tumors that colonize the entire brain.1 Beyond mechanisms inherent to tumors themselves, the discovery that tumor cells form unidirectional synaptic connections with neurons, particularly glutamatergic neurons, has transformed our understanding of glioblastoma and contributed to the foundation of the emerging field of cancer neuroscience.2-5 Previous research has demonstrated that neuronal activity accelerates glioblastoma cell growth and invasion, establishing neuron-tumor interactions as a key driver of tumor progression. Neuronal signatures have even been identified in both primary and recurrent glioblastoma, further emphasizing the role of the nervous system in disease evolution.6 |
|---|---|
| Item Description: | Gesehen am 03.03.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1523-5866 |
| DOI: | 10.1093/neuonc/noaf066 |