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Exercise facilitates post-stroke recovery through mitigation of neuronal hyperexcitability via interleukin-10 signaling

Physical exercise is an effective therapy for improving stroke recovery. However, the exact underlying molecular mechanisms of exercise-enhanced neuronal repair remain unclear. As exercise affects the immune system in healthy individuals, and the immune system in turn influences recovery after strok...

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Main Authors: Schmidt-Pogoda, Antje (Author) , Ruck, T. (Author) , Strecker, J. K. (Author) , Hoppen, M. (Author) , Fazio, L. (Author) , Vinnenberg, L. (Author) , Maus, B. (Author) , Wachsmuth, L. (Author) , Cerina, M. (Author) , Diederich, K. (Author) , Lichtenberg, S. (Author) , Abberger, H. (Author) , Haertel, L. a. L. (Author) , Schafflick, D. (Author) , Meyer zu Hörste, G. (Author) , Herrmann, A. M. (Author) , Hundehege, P. (Author) , Narayanan, V. (Author) , Nelke, C. (Author) , Kruithoff, K. (Author) , Bosbach, J. (Author) , Vicari, Elisabeth (Author) , Ramcke, Torben (Author) , Beuker, C. (Author) , Hadaschik, Eva (Author) , Budde, T. (Author) , Faber, C. (Author) , Wiendl, H. (Author) , Hansen, W. (Author) , Meuth, S. G. (Author) , Minnerup, J. (Author)
Format: Article (Journal)
Language:English
Published: 08 October 2025
In: Nature Communications
Year: 2025, Volume: 16, Issue: 1, Pages: 1-16
ISSN:2041-1723
DOI:10.1038/s41467-025-62631-y
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-025-62631-y
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-025-62631-y
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Author Notes:A. Schmidt-Pogoda, T. Ruck, J.K. Strecker, M. Hoppen, L. Fazio, L. Vinnenberg, B. Maus, L. Wachsmuth, M. Cerina, K. Diederich, S. Lichtenberg, H. Abberger, L.a.L. Haertel, D. Schafflick, G. Meyer zu Hörste, A.M. Herrmann, P. Hundehege, V. Narayanan, C. Nelke, K. Kruithoff, J. Bosbach, E. Vicari, T. Ramcke, C. Beuker, E. Hadaschik, T. Budde, C. Faber, H. Wiendl, W. Hansen, S.G. Meuth & J. Minnerup
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Summary:Physical exercise is an effective therapy for improving stroke recovery. However, the exact underlying molecular mechanisms of exercise-enhanced neuronal repair remain unclear. As exercise affects the immune system in healthy individuals, and the immune system in turn influences recovery after stroke, we hypothesized that immune mechanisms play a role in exercise-induced neurological recovery. Using a model of ischemic stroke in adult male mice, we here show that the presence of regulatory T cells (Treg) within the ischemic brain is a prerequisite for exercise-enhanced functional and structural recovery. Treg prevent excessive and sustained hyperexcitability of periinfarct neurons via IL-10 signaling. This reduced hyperexcitability precedes alterations in neuronal connectivity, which underlie functional improvement. Together, we delineate the interaction of exercise-therapy, the immune system and functional recovery after ischemic stroke. Our findings can have translational relevance for further development of immune-targeted therapies.
Item Description:Gesehen am 04.03.2026
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-025-62631-y

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