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Revising the ABIDE MCI to dementia prediction model for automated cerebrospinal fluid assays: short report

Abstract INTRODUCTION Automated cerebrospinal fluid (CSF) biomarker assays have largely replaced manual immunoassays for measuring amyloid pathology in CSF. We refitted and validated the ABIDE model, predicting progression from mild cognitive impairment (MCI) to dementia, with CSF measurements from...

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Main Authors: Van der Veere, Pieter J. (Author) , van Harten, Argonde C. (Author) , van Maurik, Ingrid S. (Author) , Teunissen, Charlotte E. (Author) , Barkhof, Frederik (Author) , Vos, Stephanie J. B. (Author) , Frölich, Lutz (Author) , Kornhuber, Johannes (Author) , Wiltfang, Jens (Author) , Maier, Wolfgang (Author) , Peters, Oliver (Author) , Rüther, Eckart (Author) , Frisoni, Giovanni B. (Author) , Spiru, Luiza (Author) , Freund-Levi, Yvonne (Author) , Wallin, Åsa K. (Author) , Hampel, Harald (Author) , Tsolaki, Magda (Author) , Kłoszewska, Iwona (Author) , Mecocci, Patrizia (Author) , Vellas, Bruno (Author) , Lovestone, Simon (Author) , Galluzzi, Samantha (Author) , Herukka, Sanna-Kaisa (Author) , Santana, Isabel (Author) , Baldeiras, I. (Author) , de Mendonca, Alexandre (Author) , Silva, Dina (Author) , Chetelat, Gael (Author) , Poisnel, Géraldine (Author) , Visser, Pieter Jelle (Author) , Johnson, Sterling C. (Author) , Stormrud, Erik (Author) , Hansson, Oskar (Author) , Palmqvist, Sebastian (Author) , Piñol-Ripoll, Gerard (Author) , Berkhof, Johannes (Author) , van der Flier, Wiesje M. (Author)
Format: Article (Journal)
Language:English
Published: February 2026
In: Alzheimer's and dementia
Year: 2026, Volume: 22, Issue: 2, Pages: 1-10
ISSN:1552-5279
DOI:10.1002/alz.71192
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/alz.71192
Verlag, kostenfrei, Volltext: https://alz-journals-onlinelibrary-wiley-com.ezproxy.medma.uni-heidelberg.de/doi/10.1002/alz.71192
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Author Notes:Pieter J. van der Veere, Argonde C. van Harten, Ingrid S. van Maurik, Charlotte E. Teunissen, Frederik Barkhof, Stephanie J.B. Vos, Lutz Froelich, Johannes Kornhuber, Jens Wiltfang, Wolfgang Maier, Oliver Peters, Eckart Rüther, Giovanni B. Frisoni, Luiza Spiru, Yvonne Freund-Levi, Åsa K. Wallin, Harald Hampel, Magda Tsolaki, Iwona Kłoszewska, Patrizia Mecocci, Bruno Vellas, Simon Lovestone, Samantha Galluzzi, Sanna-Kaisa Herukka, Isabel Santana, I. Baldeiras, Alexandre de Mendonca, Dina Silva, Gael Chetelat, Géraldine Poisnel, Pieter Jelle Visser, Sterling C. Johnson, Erik Stormrud, Oskar Hansson, Sebastian Palmqvist, Gerard Piñol-Ripoll, for the Alzheimer's Disease Neuroimaging Initiative for, Johannes Berkhof, Wiesje M. van der Flier
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Summary:Abstract INTRODUCTION Automated cerebrospinal fluid (CSF) biomarker assays have largely replaced manual immunoassays for measuring amyloid pathology in CSF. We refitted and validated the ABIDE model, predicting progression from mild cognitive impairment (MCI) to dementia, with CSF measurements from the automated Elecsys platform. METHODS We included 2413 MCI participants (998 [41%] amyloid-positive) from seven observational cohorts. Elecsys was used in 958 (40%) participants. The parameters of the previous ABIDE Cox model were re-estimated. Model discrimination and calibration were evaluated with leave-one-cohort-out cross-validation. RESULTS During follow-up, 1034 (42%; 585 [58%] amyloid-positive) participants developed dementia. Discrimination was good with Harrell's C of 0.70 (95% confidence interval [CI]: 0.66?0.73). Calibration was good in the total population and amyloid-positive subgroup, with substantial predicted progression risks for all amyloid-positive participants. DISCUSSION We refitted the ABIDE model, predicting MCI to dementia progression, with automated CSF measurements. The model was well calibrated in amyloid-positive patients and may support clinical discussions regarding ATTs.
Item Description:Erstmals veröffentlicht: 9. Februar 2026
Gesehen am 09.03.2026
Physical Description:Online Resource
ISSN:1552-5279
DOI:10.1002/alz.71192

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