Genome-wide DNA methylation patterns for indicators of liver steatosis: a longitudinal multiomic study
To identify blood DNA methylation profiles related to liver steatosis, we performed an EWAS on the presence of ultrasonically-identified liver steatosis in the Young Finns Study (YFS) participants (n = 1529, 33-50y.), and on liver enzyme levels and fatty liver index (FLI) across three discovery coho...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
03 January 2026
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| In: |
Clinical epigenetics
Year: 2026, Jahrgang: 18, Heft: 1, Pages: 1-17 |
| ISSN: | 1868-7083 |
| DOI: | 10.1186/s13148-025-02037-1 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13148-025-02037-1 |
| Verfasserangaben: | Jo Ciantar, Sonja Rajić, Daria Kostiniuk, Ella Raulamo, Noora Kartiosuo, Liye Lai, Pashupati P. Mishra, Leo-Pekka Lyytikäinen, Marcus E. Kleber, Suvi Rovio, Juha Mykkänen, Katja Pahkala, Annette Peters, Juliane Winkelmann, Winfried März, Mika Kähönen, Olli Raitakari, Terho Lehtimäki, Melanie Waldenberger, Saara Marttila and Emma Raitoharju |
| Zusammenfassung: | To identify blood DNA methylation profiles related to liver steatosis, we performed an EWAS on the presence of ultrasonically-identified liver steatosis in the Young Finns Study (YFS) participants (n = 1529, 33-50y.), and on liver enzyme levels and fatty liver index (FLI) across three discovery cohorts: YFS, LURIC (n = 2371, 17-92y.) and KORA FF4 (n = 1872, 39-88y.). We further investigated the discovered associations across the longitudinal subset of YFS (n = 255), encompassing three follow-ups over 32 years, and the three-generational YFS-3G follow-up in 2018-2020. Finally, we examined the associations of the discovered CpGs with nearby genetic variation and whole blood expression of nearby genes. |
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| Beschreibung: | Online veröffentlicht: 3. Januar 2026 Gesehen am 09.03.2026 |
| Beschreibung: | Online Resource |
| ISSN: | 1868-7083 |
| DOI: | 10.1186/s13148-025-02037-1 |