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Cognitive function in patients with myelin oligodendrocyte glycoprotein antibody-associated disease

Background: Data on cognition in adult patients with myelin oligodendrocyte glycoprotein antibody-associated disease (pwMOGAD) are scarce. Objective: To examine cognitive function in pwMOGAD and assess relative risks (RR) for cognitive impairment (CImp) in pwMOGAD relative to healthy controls (HC),...

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Main Authors: Rust, Rebekka (Author) , Asseyer, Susanna (Author) , Schindler, Patrick (Author) , Chien, Claudia (Author) , Rekers, Sophia (Author) , Finke, Carsten (Author) , Oertel, Frederike Cosima (Author) , Ruprecht, Klemens (Author) , Jarius, Sven (Author) , Wildemann, Brigitte (Author) , Chavarro, Velina (Author) , Schmitz-Hübsch, Tanja (Author) , Paul, Friedemann (Author) , Sperber, Pia Sophie (Author)
Format: Article (Journal)
Language:English
Published: 06 January 2026
In: Journal of neurology
Year: 2026, Volume: 273, Pages: 1-12
ISSN:1432-1459
DOI:10.1007/s00415-025-13582-3
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00415-025-13582-3
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Author Notes:Rebekka Rust, Susanna Asseyer, Patrick Schindler, Claudia Chien, Sophia Rekers, Carsten Finke, Frederike Cosima Oertel, Klemens Ruprecht, Sven Jarius, Brigitte Wildemann, Velina Chavarro, Tanja Schmitz-Hübsch, Friedemann Paul, Pia Sophie Sperber
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Summary:Background: Data on cognition in adult patients with myelin oligodendrocyte glycoprotein antibody-associated disease (pwMOGAD) are scarce. Objective: To examine cognitive function in pwMOGAD and assess relative risks (RR) for cognitive impairment (CImp) in pwMOGAD relative to healthy controls (HC), aquaporin 4-immunoglobulin G positive neuromyelitis optica spectrum disorders (pwAQP4+NMOSD), and double-seronegative NMOSD (pwdsNMOSD) compared to HC. Methods: Data derived from a cohort with neuroimmunological disorders. Cognitive performance was assessed using Rao’s brief repeatable battery of neuropsychological tests, compared to HC using confounder-adjusted linear regressions. CImp was defined as performing two standard deviations below the HC mean in any subtest. RR for CImp was calculated using generalized linear models. Results: We evaluated cognitive performance of 21 pwMOGAD and 25 HC. CImp was additionally determined in 43 pwAQP4+NMOSD and 15 pwdsNMOSD. PwMOGAD performed worse on Selective Reminding Test, and the symbol digit modalities test compared to HC. Adjusted RR for CImp were 1.9 (95% CI 0.9–4.1) in pwMOGAD, 1.9 (95% CI 1.0–3.9) in pwAQP4+NMOSD and 2.1 (95% CI 0.9–4.6) in pwdsNMOSD. Conclusion: pwMOGAD performed worse in information processing speed, verbal learning, storage and retrieval compared to HC. RR for CImp in pwMOGAD compared to HC was similar to that estimated for pwAQP4+NMOSD and pwdsNMOSD.
Item Description:Online veröffentlicht: 06. Januar 2026
Gesehen am 11.03.2026
Physical Description:Online Resource
ISSN:1432-1459
DOI:10.1007/s00415-025-13582-3

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