Application of a preclinical 18-gene classifier to patients with locally advanced HNSCC

In a previous preclinical trial on human HNSCC xenografts, 18 genes were predictive for adding cetuximab to fractionated radiotherapy. Here, we apply the corresponding 18-gene classifier to two HNSCC patient cohorts treated with combined radiochemotherapy (without cetuximab). We show that the classi...

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Main Authors:	Löck, Steffen (Author) , Koi, Lydia (Author) , Gurtner, Kristin (Author) , Lohaus, Fabian (Author) , Kemper, Max (Author) , Haim, Dominik (Author) , Tinhofer, Inge (Author) , Kalinauskaite, Goda (Author) , Stuschke, Martin (Author) , Fleischmann, Maximilian (Author) , Rödel, Claus (Author) , Grosu, Anca-Ligia (Author) , Debus, Jürgen (Author) , Belka, Claus (Author) , Combs, Stephanie (Author) , Boeke, Simon (Author) , Baretton, Gustavo (Author) , Baumann, Michael (Author) , Krause, Mechthild (Author) , Linge, Annett (Author)
Format:	Article (Journal) Editorial
Language:	English
Published:	January 2026
In:	Clinical and translational radiation oncology Year: 2026, Volume: 56, Pages: 1-6
ISSN:	2405-6308
DOI:	10.1016/j.ctro.2025.101067
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.ctro.2025.101067 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2405630825001594
Author Notes:	Steffen Löck, Lydia Koi, Kristin Gurtner, Fabian Lohaus, Max Kemper, Dominik Haim, Inge Tinhofer, Goda Kalinauskaite, Martin Stuschke, Maximilian Fleischmann, Claus Rödel, Anca-Ligia Grosu, Jürgen Debus, Claus Belka, Stephanie Combs, Simon Boeke, Gustavo Baretton, Michael Baumann, Mechthild Krause, Annett Linge