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Association of the rs17822931 (538G > A, G180R) in the ABCC11 gene with risk of middle ear cholesteatoma in older adults: a hospital-based case-control study at Heidelberg University Hospital, Germany

Cholesteatoma is a progressive disease characterized by abnormal proliferation of keratinizing squamous epithelium within the temporal bone. Although both congenital and acquired forms have been recognized, the molecular mechanisms underlying its development remain poorly understood. Although surger...

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Main Authors: Nakagawa, Hiroshi (Author) , Imai, Ritsuko (Author) , Gestewitz, Martin (Author) , Praetorius, Mark (Author) , Tsukamoto, Megumi (Author) , Albrecht, Tobias (Author) , Kusunoki, Takeshi (Author) , Ikeda, Katsuhisa (Author) , Sertel, Serkan (Author)
Format: Article (Journal)
Language:English
Published: 06 January 2026
In: European archives of oto-rhino-laryngology and head & neck
Year: 2026, Pages: 1-6
ISSN:1434-4726
DOI:10.1007/s00405-025-09933-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00405-025-09933-5
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Author Notes:Hiroshi Nakagawa, Ritsuko Imai, Martin Gestewitz, Mark Praetorius, Megumi Tsukamoto, Tobias Albrecht, Takeshi Kusunoki, Katsuhisa Ikeda, Serkan Sertel
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Summary:Cholesteatoma is a progressive disease characterized by abnormal proliferation of keratinizing squamous epithelium within the temporal bone. Although both congenital and acquired forms have been recognized, the molecular mechanisms underlying its development remain poorly understood. Although surgery is the only curative option, the high recurrence rates underscore the need to identify genetic risk factors. The rs17822931 (538G > A, G180R) polymorphism in the ABCC11 gene has been associated with cholesteatoma risk in the Japanese population. However, ethnic variation in the frequencies of SNPs other than rs17822931 raises the question of whether its involvement in cholesteatoma development is unique to the Japanese population or generalizable to other ethnic groups.
Item Description:Online veröffentlicht: 06. Januar 2026
Gesehen am 11.03.2026
Physical Description:Online Resource
ISSN:1434-4726
DOI:10.1007/s00405-025-09933-5

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