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A hitchhiker's guide to cerebrospinal fluid biomarkers for neuro-oncology

Cerebrospinal fluid (CSF) has emerged as a valuable liquid biopsy source for glioma biomarker discovery and validation. CSF produced within the ventricles circulates through the subarachnoid space, where the composition of glioma-derived analytes is influenced by the proximity and anatomical locatio...

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Main Authors: Riviere-Cazaux, Cecile (Author) , Keough, Michael B. (Author) , Zuccato, Jeffrey A. (Author) , Kumar, Rahul (Author) , Schulz, Sebastian C. (Author) , Warrington, Arthur E. (Author) , Ruff, Michael W. (Author) , Ellingson, Benjamin M. (Author) , Sanai, Nader (Author) , Campian, Jian L. (Author) , Kizilbash, Sani H. (Author) , Parney, Ian F. (Author) , Zadeh, Gelareh (Author) , Khasraw, Mustafa (Author) , Keßler, Tobias (Author) , Sener, Ugur (Author) , Cahill, Daniel P. (Author) , Mansouri, Alireza (Author) , Burns, Terry C. (Author)
Format: Article (Journal)
Language:English
Published: 2025
In: Neuro-Oncology
Year: 2025, Volume: 27, Issue: 5, Pages: 1165-1179
ISSN:1523-5866
DOI:10.1093/neuonc/noae276
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1093/neuonc/noae276
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Author Notes:Cecile Riviere-Cazaux, Michael B. Keough, Jeffrey A. Zuccato, Rahul Kumar, Sebastian C. Schulz, Arthur E. Warrington, Michael W. Ruff, Benjamin M. Ellingson, Nader Sanai, Jian L. Campian, Sani H. Kizilbash, Ian F. Parney, Gelareh Zadeh, Mustafa Khasraw, Tobias Kessler, Ugur Sener, Daniel P. Cahill, Alireza Mansouri, and Terry C. Burns
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Summary:Cerebrospinal fluid (CSF) has emerged as a valuable liquid biopsy source for glioma biomarker discovery and validation. CSF produced within the ventricles circulates through the subarachnoid space, where the composition of glioma-derived analytes is influenced by the proximity and anatomical location of sampling relative to tumor, in addition to underlying tumor biology. The substantial gradients observed between lumbar and intracranial CSF compartments for tumor-derived analytes underscore the importance of sampling site selection. Moreover, radiographic features, such as tumor-CSF contact and blood-brain barrier disruption, are critical covariates that may affect biomarker detection and the abundance of plasma-derived analytes in CSF, respectively. Longitudinal intracranial CSF sampling, enabled by access devices like Ommaya reservoirs, may offer a window into treatment response and disease progression, though variability in analyte yield, sample volumes, and the dynamic effects of surgical resection pose challenges. This review critically evaluates the anatomic, radiographic, and longitudinal factors, or "time-space continuum," that impact glioma CSF biomarker abundance. Practical considerations for longitudinal CSF biobanking, including access device placement and collection, are also reviewed. Key takeaways and recommendations for CSF glioma biomarker discovery and validation are provided as a "hitchhiker's guide" based on our collective experience, along with resources for investigators aiming to develop CSF biobanking at their institutions.
Item Description:Online verfügbar: 30 December 2024
Gesehen am 11.03.2026
Physical Description:Online Resource
ISSN:1523-5866
DOI:10.1093/neuonc/noae276

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