Cover Image

Current practices in the study of biomolecular condensates: a community comment

The realization that the cell is abundantly compartmentalized into biomolecular condensates has opened new opportunities for understanding the physics and chemistry underlying many cellular processes1, fundamentally changing the study of biology2. The term biomolecular condensate refers to non-stoic...

Full description

Saved in:
Bibliographic Details
Main Authors: Alberti, Simon Marc (Author) , Arosio, Paolo (Author) , Best, Robert B. (Author) , Boeynaems, Steven (Author) , Cai, Danfeng (Author) , Collepardo-Guevara, Rosana (Author) , Dignon, Gregory L. (Author) , Dimova, Rumiana (Author) , Elbaum-Garfinkle, Shana (Author) , Fawzi, Nicolas L. (Author) , Fuxreiter, Monika (Author) , Gladfelter, Amy S. (Author) , Honigmann, Alf (Author) , Jain, Ankur (Author) , Joseph, Jerelle A. (Author) , Knowles, Tuomas P. J. (Author) , Lasker, Keren (Author) , Lemke, Edward A. (Author) , Lindorff-Larsen, Kresten (Author) , Lipowsky, Reinhard (Author) , Mittal, Jeetain (Author) , Mukhopadhyay, Samrat (Author) , Myong, Sua (Author) , Pappu, Rohit V. (Author) , Rippe, Karsten (Author) , Shelkovnikova, Tatyana A. (Author) , Vecchiarelli, Anthony G. (Author) , Wegmann, Susanne (Author) , Zhang, Huaiying (Author) , Zhang, Mingjie (Author) , Zubieta, Chloe (Author) , Zweckstetter, Markus (Author) , Dormann, Dorothee (Author) , Mittag, Tanja (Author)
Format: Article (Journal)
Language:English
Published: 2025
In: Nature Communications
Year: 2025, Volume: 16, Pages: 1-14
ISSN:2041-1723
DOI:10.1038/s41467-025-62055-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-025-62055-8
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-025-62055-8
Get full text
Author Notes:Simon Alberti, Paolo Arosio, Robert B. Best, Steven Boeynaems, Danfeng Cai, Rosana Collepardo-Guevara, Gregory L. Dignon, Rumiana Dimova, Shana Elbaum-Garfinkle, Nicolas L. Fawzi, Monika Fuxreiter, Amy S. Gladfelter, Alf Honigmann, Ankur Jain, Jerelle A. Joseph, Tuomas P. J. Knowles, Keren Lasker, Edward A. Lemke, Kresten Lindorff-Larsen, Reinhard Lipowsky, Jeetain Mittal, Samrat Mukhopadhyay, Sua Myong, Rohit V. Pappu, Karsten Rippe, Tatyana A. Shelkovnikova, Anthony G. Vecchiarelli, Susanne Wegmann, Huaiying Zhang, Mingjie Zhang, Chloe Zubieta, Markus Zweckstetter, Dorothee Dormann & Tanja Mittag
Description
Summary:The realization that the cell is abundantly compartmentalized into biomolecular condensates has opened new opportunities for understanding the physics and chemistry underlying many cellular processes1, fundamentally changing the study of biology2. The term biomolecular condensate refers to non-stoichiometric assemblies that are composed of multiple types of macromolecules in cells, occur through phase transitions, and can be investigated by using concepts from soft matter physics3. As such, they are intimately related to aqueous two-phase systems4 and water-in-water emulsions5. Condensates possess tunable emergent properties such as interfaces, interfacial tension, viscoelasticity, network structure, dielectric permittivity, and sometimes interphase pH gradients and electric potentials6-14. They can form spontaneously in response to specific cellular conditions or to active processes, and cells appear to have mechanisms to control their size and location15-17. Importantly, in contrast to membrane-enclosed organelles such as mitochondria or peroxisomes, condensates do not require the presence of a surrounding membrane.
Item Description:Online veröffentlicht: 19. August 2025
Gesehen am 11.03.2026
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-025-62055-8

Similar Items