68Gallium-labelled fibroblast activation protein inhibitor uptake in joints: a single-center cohort analysis of 268 patients
Musculoskeletal diseases such as osteoarthritis (OA) are leading causes of pain, physical inactivity and disability worldwide. Synovial fibroblasts (SFs) expressing fibroblast activation protein (FAP) are crucial for OA progression. Positron emission tomography (PET) with 68Gallium-labelled FAP-inhi...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 November 2025
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| In: |
European journal of nuclear medicine and molecular imaging
Year: 2025, Pages: ? |
| ISSN: | 1619-7089 |
| DOI: | 10.1007/s00259-025-07636-x |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00259-025-07636-x |
| Verfasserangaben: | Anna-Maria Spektor, Antonia van Genabith, Jorge Hoppner, Leon Walkenbach, Thomas Hielscher, Peter Kvacskay, Sarah Richter, Kiangenda Trésor Sungu-Winkler, Hans-Ulrich Kauczor, Hanns-Martin Lorenz, Mathias Schreckenberger, Jörg Distler, Uwe Haberkorn, Wolfgang Merkt, Manuel Röhrich |
| Zusammenfassung: | Musculoskeletal diseases such as osteoarthritis (OA) are leading causes of pain, physical inactivity and disability worldwide. Synovial fibroblasts (SFs) expressing fibroblast activation protein (FAP) are crucial for OA progression. Positron emission tomography (PET) with 68Gallium-labelled FAP-inhibitors (68 Ga-FAPI) visualizes FAP-positive activated fibroblasts. Here, we systematically analyze FAPI-uptake respecting OA and joint degeneration in a cohort of 268 patients. |
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| Beschreibung: | Im Text ist "68" hochgestellt Gesehen am 13.03.2026 |
| Beschreibung: | Online Resource |
| ISSN: | 1619-7089 |
| DOI: | 10.1007/s00259-025-07636-x |