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68Gallium-labelled fibroblast activation protein inhibitor uptake in joints: a single-center cohort analysis of 268 patients

Musculoskeletal diseases such as osteoarthritis (OA) are leading causes of pain, physical inactivity and disability worldwide. Synovial fibroblasts (SFs) expressing fibroblast activation protein (FAP) are crucial for OA progression. Positron emission tomography (PET) with 68Gallium-labelled FAP-inhi...

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Main Authors: Spektor, Anna-Maria (Author) , van Genabith, Antonia (Author) , Hoppner, Jorge (Author) , Walkenbach, Leon (Author) , Hielscher, Thomas (Author) , Kvacskay, Peter (Author) , Richter, Sarah (Author) , Sungu-Winkler, Kiangenda Trésor (Author) , Kauczor, Hans-Ulrich (Author) , Lorenz, Hanns-Martin (Author) , Schreckenberger, Mathias (Author) , Distler, Jörg (Author) , Haberkorn, Uwe (Author) , Merkt, Wolfgang (Author) , Röhrich, Manuel (Author)
Format: Article (Journal)
Language:English
Published: 2026
In: European journal of nuclear medicine and molecular imaging
Year: 2025, Volume: 53, Pages: 3226-3237
ISSN:1619-7089
DOI:10.1007/s00259-025-07636-x
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00259-025-07636-x
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Author Notes:Anna-Maria Spektor, Antonia van Genabith, Jorge Hoppner, Leon Walkenbach, Thomas Hielscher, Peter Kvacskay, Sarah Richter, Kiangenda Trésor Sungu-Winkler, Hans-Ulrich Kauczor, Hanns-Martin Lorenz, Mathias Schreckenberger, Jörg Distler, Uwe Haberkorn, Wolfgang Merkt, Manuel Röhrich
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Summary:Musculoskeletal diseases such as osteoarthritis (OA) are leading causes of pain, physical inactivity and disability worldwide. Synovial fibroblasts (SFs) expressing fibroblast activation protein (FAP) are crucial for OA progression. Positron emission tomography (PET) with 68Gallium-labelled FAP-inhibitors (68 Ga-FAPI) visualizes FAP-positive activated fibroblasts. Here, we systematically analyze FAPI-uptake respecting OA and joint degeneration in a cohort of 268 patients.
Item Description:Veröffentlicht: 20 November 2025
Im Text ist "68" hochgestellt
Gesehen am 13.03.2026
Physical Description:Online Resource
ISSN:1619-7089
DOI:10.1007/s00259-025-07636-x

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