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Factors associated with all-cause mortality and morbidity of motorcycle crash-related neurological and musculoskeletal injuries in Uganda: the MOTOR cluster randomised trial ancillary study

Introduction This study examined the factors linked to all-cause mortality and morbidity from neurological and musculoskeletal injuries during motorcycle accidents in Uganda. - Methods The study was part of a two-armed, parallel, multi-period, cluster-randomised controlled trial of 1003 motorcycle c...

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Main Authors: Lule, Herman (Author) , Mugerwa, Micheal (Author) , Abio, Anne (Author) , Oguttu, Benson (Author) , Kakeeto, Andrew (Author) , Asiimwe, Daniel (Author) , Lekuya, Hervé Monka Monka (Author) , Ssebuufu, Robinson (Author) , Kyamanywa, Patrick (Author) , Bärnighausen, Till (Author) , Wilson, Michael L. (Author) , Posti, Jussi P. (Author)
Format: Article (Journal)
Language:English
Published: January 2, 2026
In: Injury prevention
Year: 2026, Pages: 1-6
ISSN:1475-5785
DOI:10.1136/ip-2025-045737
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1136/ip-2025-045737
Verlag, kostenfrei, Volltext: https://injuryprevention.bmj.com/content/early/2026/01/02/ip-2025-045737
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Author Notes:Herman Lule, Micheal Mugerwa, Anne Abio, Benson Oguttu, Andrew Kakeeto, Daniel Asiimwe, Hervé Monka Monka Lekuya, Robinson Ssebuufu, Patrick Kyamanywa, Till Bärnighausen, Michael L Wilson, Jussi P Posti
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Summary:Introduction This study examined the factors linked to all-cause mortality and morbidity from neurological and musculoskeletal injuries during motorcycle accidents in Uganda. - Methods The study was part of a two-armed, parallel, multi-period, cluster-randomised controlled trial of 1003 motorcycle crash victims. Morbidity was assessed using various scoring systems, and mixed effects regression models were employed for analysis. - Results Ninety-day all-cause mortality was 9.2% (82/887). Factors associated with mortality included referral-to-dispatch >1 hour (OR 4.215 (1.802-9.858), p=0.001), Kampala Trauma Score (KTS) ≤6 (OR 7.696 (1.932-30.653), p=0.004), GCS 9-12 (OR 3.432 (1.194-9.870), p=0.022), GCS ≤8 (OR 6.919 (2.212-21.645), p=0.001), intra-axial lesions (OR 78.647 (9.871-626.587), p<0.001), extra-axial lesions (OR 11.933 (1.386-102.750), p=0.024), skull fracture (OR 11.366, (1.197-107.977), p=0.034) and craniotomy (OR 0.260 (0.095-0.706), p=0.008).A percentage of 14.5% had unfavourable Glasgow Outcome Scale (1-3); associated factors included increasing age (OR 1.02 (1.013-1.045, p<.001), multiple injuries (OR 4.559 (1.185-17.531), p=0.027), KTS 7-8 (OR 2.755 (1.285-5.906), p=0.009), KTS ≤6 (OR 7.551 (2.815-20.255), p=0.001), GCS 9-12 (OR 4.07 (1.901-8.719), p=0.001), GCS ≤8 (OR 13.779 (5.643-33.645), p<0.001) and craniotomy (OR 0.149 (0.075-0.295), p<0.001).Factors associated with unfavourable patient-reported musculoskeletal outcomes included being married (OR 1.984 (1.322-2.976), p=0.001), multiple injuries (OR 1.762 (1.001-3.100), p=0.049) and enrolment after the onset of the COVID-19 pandemic (OR 2.095 (1.199-3.659), p=0.009]. - Conclusions The key determinants of mortality and adverse neurological and musculoskeletal injury outcomes observed in this study are essential for establishing core outcome sets in future research and predictive models. - Trial registration number Pan African Clinical Trial Registry (PACTR202308851460352).
Item Description:Zuerst veröffentlicht: 2. Januar 2026
Gesehen am 13.03.2026
Physical Description:Online Resource
ISSN:1475-5785
DOI:10.1136/ip-2025-045737

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