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Nutrient requirements of organ-specific metastasis in breast cancer

Cancer metastasis is a major contributor to patient morbidity and mortality1, yet the factors that determine the organs where cancers can metastasize are incompletely understood. Here we quantify the absolute levels of 124 metabolites in multiple tissues in mice and investigate how this relates to t...

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Main Authors: Abbott, Keene (Author) , Subudhi, Sonu (Author) , Ferreira, Raphael (Author) , Gültekin, Yetiş (Author) , Steinbuch, Sophie C. (Author) , Munim, Muhammad Bin (Author) , Ramesh, Diya L. (Author) , Honeder, Sophie E. (Author) , Kumar, Ashwin S. (Author) , Wu, Michelle (Author) , Hansen, Jacob A. (Author) , Shevzov-Zebrun, Anna (Author) , Rashan, Edrees H. (Author) , Eghbalian, Kian (Author) , Sivanand, Sharanya (Author) , Barbeau, Anna M. (Author) , Riedmayr, Lisa M. (Author) , Duquette, Mark (Author) , Ali, Ahmed (Author) , Henning, Nicole (Author) , Trojan, Sonia E. (Author) , Waite, Millenia (Author) , Kunchok, Tenzin (Author) , Nakano, Mayu A. (Author) , Gourgue, Florian (Author) , Ferraro, Gino B. (Author) , Do, Brian T. (Author) , Spanoudaki, Virginia (Author) , Sánchez-Rivera, Francisco J. (Author) , Jin, Xin (Author) , Church, George M. (Author) , Jain, Rakesh K. (Author) , Vander Heiden, Matthew G. (Author)
Format: Article (Journal)
Language:English
Published: 29 January 2026
In: Nature
Year: 2026, Volume: 649, Issue: 8099, Pages: 1292-1301, [1-31]
ISSN:1476-4687
DOI:10.1038/s41586-025-09898-9
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41586-025-09898-9
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41586-025-09898-9
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Author Notes:Keene L. Abbott, Sonu Subudhi, Raphael Ferreira, Yetiş Gültekin, Sophie C. Steinbuch, Muhammad Bin Munim, Diya L. Ramesh, Sophie E. Honeder, Ashwin S. Kumar, Michelle Wu, Jacob A. Hansen, Anna Shevzov-Zebrun, Edrees H. Rashan, Kian M. Eghbalian, Sharanya Sivanand, Anna M. Barbeau, Lisa M. Riedmayr, Mark Duquette, Ahmed Ali, Nicole Henning, Sonia E. Trojan, Millenia Waite, Tenzin Kunchok, Mayu A. Nakano, Florian Gourgue, Gino B. Ferraro, Brian T. Do, Virginia Spanoudaki, Francisco J. Sánchez-Rivera, Xin Jin, George M. Church, Rakesh K. Jain & Matthew G. Vander Heiden
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Summary:Cancer metastasis is a major contributor to patient morbidity and mortality1, yet the factors that determine the organs where cancers can metastasize are incompletely understood. Here we quantify the absolute levels of 124 metabolites in multiple tissues in mice and investigate how this relates to the ability of breast cancer cells to grow in different organs. We engineered breast cancer cells with broad metastatic potential to be auxotrophic for specific nutrients and assessed their ability to colonize different tissue sites. We then asked how tumour growth in different tissues relates to nutrient availability and tumour biosynthetic activity. We find that single nutrients alone do not define the sites where breast cancer cells can grow as metastases. In addition, we identify purine synthesis as a requirement for tumour growth and metastasis across many tissues and find that this phenotype is independent of tissue nucleotide availability or tumour de novo nucleotide synthesis activity. These data suggest that a complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth, and highlights the interdependence between extrinsic environmental factors and intrinsic cellular properties in influencing where breast cancer cells can grow as metastases.
Item Description:Online veröffentlicht: 7. Januar 2026
Gesehen am 16.03.2026
Physical Description:Online Resource
ISSN:1476-4687
DOI:10.1038/s41586-025-09898-9

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