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A multi-dimensional framework for establishing and managing a genomic newborn screening program

Newborn screening (NBS) is an effective measure of secondary prevention. The application of genomic sequencing in population-based screening would enable further expansions of the NBS disease panel and a genomic NBS (gNBS). The selection of NBS target diseases is still based on the Wilson and Jungne...

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Main Authors: Schnabel-Besson, Elena (Author) , Dikow, Nicola (Author) , Alex, Karla (Author) , Mütze, Ulrike (Author) , Straub, Hannah (Author) , Doll, Elena Sophia (Author) , Mahal, Julia (Author) , Brennenstuhl, Heiko (Author) , Mayer, Carlotta Julia (Author) , Neth, Lars (Author) , Hagedorn, Tobias (Author) , Högl, Henriette (Author) , Settegast, Sascha (Author) , Ditzen, Beate (Author) , Müller-Terpitz, Ralf (Author) , Kölker, Stefan (Author) , Schaaf, Christian P. (Author) , Winkler, Eva C. (Author)
Format: Article (Journal)
Language:English
Published: 28 February 2026
In: European journal of human genetics
Year: 2026, Pages: 1-9
ISSN:1476-5438
DOI:10.1038/s41431-026-02045-6
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41431-026-02045-6
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41431-026-02045-6
Resolving-System, kostenfrei: https://doi.org/10.1038/s41431-026-02045-6
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Author Notes:Elena Schnabel-Besson, Nicola Dikow, Karla Alex, Ulrike Mütze, Hannah Straub, Elena Sophia Doll, Julia Mahal, Heiko Brennenstuhl, Carlotta Julia Mayer, Lars Neth, Tobias Hagedorn, Henriette Högl, Sascha Settegast, Beate Ditzen, Ralf Müller-Terpitz, Stefan Kölker, Christian P. Schaaf and Eva Winkler
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Summary:Newborn screening (NBS) is an effective measure of secondary prevention. The application of genomic sequencing in population-based screening would enable further expansions of the NBS disease panel and a genomic NBS (gNBS). The selection of NBS target diseases is still based on the Wilson and Jungner screening principles from 1968, which are considered incomplete, particularly for an extension towards gNBS. The present work aims to establish a multi-dimensional framework for future gNBS programs. An interdisciplinary expert panel comprising researchers from pediatric and adolescent medicine, human genetics, ethics, medical psychology, law, and patient representatives used a nominal group technique-like multi-stage consensus process to define criteria for gNBS, considering ethical, legal, and social implications, medical aspects, and patient perspectives. Overall, 18 criteria were developed, clustered into four subcategories: I. Clinical criteria (characteristics of the target disease); II. Diagnostic criteria (requirements of the test); III. Therapeutic-interventional criteria (prerequisites of the intervention); IV. Program management criteria (requirements of the program). Subcategories I-III define selection criteria for target diseases, subcategory IV defines criteria for how to establish and manage the program. In conclusion, this multi-dimensional framework serves as a well-balanced basis for developing thoroughly revised and internationally accepted consensus screening criteria.
Item Description:Gesehen am 01.04.2026
Physical Description:Online Resource
ISSN:1476-5438
DOI:10.1038/s41431-026-02045-6

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