Deep brain stimulation for post-stroke movement disorders of various etiologies: an individual participant data (IPD) meta-analysis
Background Post-stroke movement disorders consisting of complex involuntary movement patterns with parkinsonism, dystonia, hemiballismus/hemichorea, and tremor represent a therapeutical challenge. Deep brain stimulation has been considered an effective treatment option, although it remains unclear w...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 2026
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| In: |
Brain and behavior
Year: 2026, Volume: 16, Issue: 2, Pages: 1-13 |
| ISSN: | 2162-3279 |
| DOI: | 10.1002/brb3.71270 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/brb3.71270 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/brb3.71270 
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| Author Notes: | Thomas Kinfe, Sanjay Pandey, Martin Regensburger, Maximilian Zaubitzer, Achim Schilling, Steffen Brenner |
| Summary: | Background Post-stroke movement disorders consisting of complex involuntary movement patterns with parkinsonism, dystonia, hemiballismus/hemichorea, and tremor represent a therapeutical challenge. Deep brain stimulation has been considered an effective treatment option, although it remains unclear which DBS targets should be approached. Methods An individual participant data meta-analysis was conducted analyzing the efficacy (Burke Fahn Marsden Dystonia Rating Scale (BFM)-motor/-disability and the Fahn-Tolosa-Marín Scale for tremor (FTMTRS)) of pallidal (GPi) deep brain stimulation versus thalamic (VIM) versus GPi + VIM. PubMed, Embase, Cochrane Library, Ovid Medline, and Scopus were searched from 2000 to 2025. Additionally, correlation/regression analyses (age, duration of disease, stimulation parameters) were performed. Results Sixteen studies including 32 patients (34.4% male; 65.6% female) were enrolled targeting the GPi (63.2%) versus VIM (23.6%) versus GPi/VIM-DBS (13.2%). Dystonia with tremor was found in 53%, dystonia with hemichorea/choreoathetosis in 50% (age at disease onset: 10 ± 18 years, age at DBS surgery: 37 ± 15 years, disease duration: 28 ± 19 years). GPi-DBS improved dystonia (BFM-motor: 6-12 months p < 0.005 and >12 months p = 0.038; BFM-disability 6-12 months p = 0.038) with no significant/relevant changes for VIM and GPi/VIM. No correlations were determined between DBS outcome and stimulation protocol and demographic characteristics. Adverse events occurred in 19%. Conclusion DBS is effective for treating post-stroke movement disorders of various etiologies. Given the heterogeneity, selection, and reporting bias, the published data is limited in providing high-quality evidence. Hence, the authors advocate a multifocal DBS approach along with trial stimulation determined under a rigorous study protocol. |
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| Item Description: | Erstmals veröffentlicht: 16. Februar 2026 Gesehen am 19.03.2026 |
| Physical Description: | Online Resource |
| ISSN: | 2162-3279 |
| DOI: | 10.1002/brb3.71270 |