Stromal immune cell signatures predict risk of progression in meningioma
By investigating single-cell gene expression and DNA methylation profiles of meningiomas, we found that the composition of the tumor microenvironment and cellular activation status both correlate with tumor aggressiveness. These findings explain the outcomes of previous DNA methylation-based classif...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 2026
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| In: |
Nature genetics
Year: 2026, Volume: 58, Issue: 2, Pages: 245-246 |
| ISSN: | 1546-1718 |
| DOI: | 10.1038/s41588-025-02476-9 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41588-025-02476-9 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41588-025-02476-9 
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| Author Notes: | Sybren L.N. Maas & Felix Sahm |
| Summary: | By investigating single-cell gene expression and DNA methylation profiles of meningiomas, we found that the composition of the tumor microenvironment and cellular activation status both correlate with tumor aggressiveness. These findings explain the outcomes of previous DNA methylation-based classification approaches to meningioma and have direct clinical applicability. |
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| Item Description: | Online veröffentlicht: 09. Februar 2026 Gesehen am 23.03.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1546-1718 |
| DOI: | 10.1038/s41588-025-02476-9 |