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Renal function during tenofovir‑based antiretroviral therapy among people living with HIV in Lilongwe, Malawi: findings from the prospective LighTen cohort study

Most first-line antiretroviral therapy (ART) regimes in Sub-Saharan Africa contain tenofovir disoproxil fumarate (TDF) which has a nephrotoxic potential. Baseline renal function assessment is not feasible in many settings and therefore not required prior to starting ART according to Malawian guideli...

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Main Authors: Mahanani, Melani Ratih (Author) , Neuhann, Florian (Author) , Rambiki, Ethel (Author) , Nhlema, Angelina (Author) , Tweya, Hannock (Author) , Chit, Myo (Author) , Chiwoko, Jane (Author) , Chaweza, Thom (Author) , Wallrauch, Claudia (Author) , Heller, Tom (Author) , Winkler, Volker (Author) , Fätkenheuer, Gerd (Author) , Steffen, Hans-Michael (Author)
Format: Article (Journal)
Language:English
Published: December 2026
In: BMC infectious diseases
Year: 2026, Volume: 26, Issue: 1, Pages: 1-10
ISSN:1471-2334
DOI:10.1186/s12879-026-12675-2
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12879-026-12675-2
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Author Notes:Melani R. Mahanani, Florian Neuhann, Ethel Rambiki, Angelina Nhlema, Hannock Tweya, Myo Chit, Jane Chiwoko, Thom Chaweza, Claudia Wallrauch, Tom Heller, Volker Winkler, Gerd Fätkenheuer and Hans-Michael Steffen
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Summary:Most first-line antiretroviral therapy (ART) regimes in Sub-Saharan Africa contain tenofovir disoproxil fumarate (TDF) which has a nephrotoxic potential. Baseline renal function assessment is not feasible in many settings and therefore not required prior to starting ART according to Malawian guidelines. We assessed renal function over 36 months in people living with HIV (PLHIV) starting TDF-based ART at Lighthouse Clinic, Lilongwe, Malawi.
Item Description:Online veröffentlicht: 28. Januar 2026, Artikelversion: 20. Februar 2026
Gesehen am 23.03.2026
Physical Description:Online Resource
ISSN:1471-2334
DOI:10.1186/s12879-026-12675-2

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