Cover Image

Endobronchial ultrasound-guided mediastinal biopsies for the diagnosis of mediastinal diseases: a network meta-analysis

BackgroundClinical guidelines recommend endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) as the initial diagnostic tool for lung cancer staging. However, despite the availability of mediastinal forceps biopsy and cryobiopsy, the optimal diagnostic approaches for other med...

Full description

Saved in:
Bibliographic Details
Main Authors: Qi, Yong-Jia (Author) , Zhang, Jing (Author) , Lobera, Esperanza Salcedo (Author) , Song, Qiu-Yue (Author) , Zhong, Ren-Hai (Author) , Kontogianni, Konstantina (Author) , Huang, Zan-Sheng (Author) , Ariza-Prota, Miguel (Author) , Gupta, Nitesh (Author) , Madan, Manu (Author) , Maturu, Venkata Nagarjuna (Author) , Prasad, Virender Pratibh (Author) , Steinack, Carolin (Author) , Wu, Na (Author) , Gaisl, Thomas (Author) , Herth, Felix (Author) , Fan, Ye (Author)
Format: Article (Journal)
Language:English
Published: 2026
In: Pulmonology
Year: 2026, Volume: 32, Issue: 1, Pages: 1-11
ISSN:2531-0437
DOI:10.1080/25310429.2025.2593067
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/25310429.2025.2593067
Get full text
Author Notes:Yong-Jia Qi, Jing Zhang, Esperanza Salcedo Lobera, Qiu-Yue Song, Ren-Hai Zhong, Konstantina Kontogianni, Zan-Sheng Huang, Miguel Ariza-Prota, Nitesh Gupta, Manu Madan, Venkata Nagarjuna Maturu, Virender Pratibh Prasad, Carolin Steinack, Na Wu, Thomas Gaisl, Felix J. F. Herth, and Ye Fan
Description
Summary:BackgroundClinical guidelines recommend endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) as the initial diagnostic tool for lung cancer staging. However, despite the availability of mediastinal forceps biopsy and cryobiopsy, the optimal diagnostic approaches for other mediastinal conditions remain unclear.MethodsWe searched multiple databases and sources up to February 21, 2025, and employed single-arm, pairwise, and network meta-analytical approaches to comprehensively evaluate EBUS-based biopsies for mediastinal diseases in terms of efficacy and safety.ResultsFifteen prospective studies including 1,316 participants evaluated five EBUS-based mediastinal biopsy strategies (EBUS-TBNA, forceps biopsy, cryobiopsy, and the combinations of EBUS-TBNA with forceps biopsy or cryobiopsy) were involved. Concomitant EBUS-TBNA enhanced the efficacy of both forceps biopsy and cryobiopsy. EBUS-TBNA plus cryobiopsy yielded the best diagnostic outcome, showing significant benefits over EBUS-TBNA (OR 4.01, 95% CrI 3.05-5.33), forceps biopsy (OR 2.75, 95% CrI 1.94-3.92), cryobiopsy (OR 1.80, 95% CrI 1.33-2.45), and EBUS-TBNA plus forceps biopsy (OR 1.81, 95% CrI 1.20-2.72). A similarly favourable safety profile was observed in all EBUS-based biopsy methods.ConclusionsEBUS-TBNA is the diagnostic cornerstone for mediastinal lesions, with EBUS-TBNA plus cryobiopsy being most effective. All EBUS-guided biopsies demonstrated a favourable safety profile.
Item Description:Gesehen am 25.03.2026
Physical Description:Online Resource
ISSN:2531-0437
DOI:10.1080/25310429.2025.2593067

Similar Items