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Neoadjuvant treatment is a risk factor for clinically relevant chyle leak (ISGPS Grade B/C) after pancreatic cancer resection: a retrospective cohort study

Chyle leak is a relevant complication after surgery for pancreatic ductal adenocarcinoma (PDAC). Increasing use of multimodal neoadjuvant therapy (NAT) and extended resections may contribute to a higher incidence. This study aimed to describe the incidence of clinically relevant chyle leak and ident...

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Main Authors: Leonhardt, Carl-Stephan (Author) , Shraim, Sakher (Author) , Abdelazim, Karim (Author) , Hinz, Ulf (Author) , Polychronidis, Georgios (Author) , Hank, Thomas (Author) , Schneider, Martin (Author) , Hackert, Thilo (Author) , Strobel, Oliver (Author) , Loos, Martin (Author) , Büchler, Markus W. (Author) , Saeedi, Mohammed al (Author)
Format: Article (Journal)
Language:English
Published: 2026
In: Annals of surgical oncology
Year: 2026, Volume: 33, Issue: 3, Pages: 2674-2682
ISSN:1534-4681
DOI:10.1245/s10434-025-18698-4
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1245/s10434-025-18698-4
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Author Notes:Carl‑Stephan Leonhardt, MD, Sakher Shraim, MD, Karim Abdelazim, MD, Ulf Hinz, MSc, Georgios Polychronidis, MD, Thomas Hank, MD, Martin Schneider, MD, Thilo Hackert, MD, Oliver Strobel, MD, Martin Loos, MD, Markus W. Buechler, MD, and Mohammed Al‑Saeedi, MD
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Summary:Chyle leak is a relevant complication after surgery for pancreatic ductal adenocarcinoma (PDAC). Increasing use of multimodal neoadjuvant therapy (NAT) and extended resections may contribute to a higher incidence. This study aimed to describe the incidence of clinically relevant chyle leak and identify its risk factors in patients with PDAC treated with NAT and surgery versus upfront surgery.
Item Description:Online veröffentlicht: 21 November 2025
Gesehen am 25.03.2026
Physical Description:Online Resource
ISSN:1534-4681
DOI:10.1245/s10434-025-18698-4

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