Glucose control during 3-month treatment with bihormonal artificial pancreas versus current diabetes care in patients after total pancreatectomy: study protocol for the PANORAMA randomized crossover trial

Patients undergoing total pancreatectomy (TP) will develop insulin-dependent diabetes, which is challenging to manage due to the complete absence of insulin and glucagon1. In recent years, the first European Commission-marked bihormonal artificial pancreas (BIHAP; Inreda Diabetic, Goor, the Netherla...

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Main Authors:	Lesemann, Charlotte A. (Author) , Veldhuisen, Charlotte L. van (Author) , Rompen, Ingmar F. (Author) , Bouwense, Stefan A. (Author) , Bosscha, Koop (Author) , Busch, Olivier R. (Author) , Dijkgraaf, Marcel G. W. (Author) , Eijck, Casper H. J. van (Author) , Haan, Job S. de (Author) , Haen, Roel (Author) , Hingh, Ignace H. J. de (Author) , Meijer, V. de (Author) , Nijkamp, Maarten W. (Author) , Mieog, J. Sven D. (Author) , Molenaar, I. Quintus (Author) , Santvoort, Hjalmar. (Author) , Stommel, Martijn W. J. (Author) , Voermans, Rogier P. (Author) , Wilmink, Johanna W. (Author) , De Vries, J. Hans (Author) , Besselink, Marc G. (Author)
Format:	Article (Journal) Editorial
Language:	English
Published:	February 2026
In:	BJS open Year: 2026, Volume: 10, Pages: 1-2
ISSN:	2474-9842
DOI:	10.1093/bjsopen/zraf151
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/bjsopen/zraf151
Author Notes:	Charlotte A Leseman, Charlotte L van Veldhuisen, Ingmar F Rompen, Stefan A Bouwense, Koop Bosscha, Olivier R Busch, Marcel GW Dijkgraaf, Casper HJ van Eijck, Job S de Haan, Roel Haen, Ignace HJ de Hingh, V de Meijer, Maarten W Nijkamp, J Sven D Mieog, I Quintus Molenaar, Hjalmar C van Santvoort, Martijn WJ Stommel, Rogier P Voermans, Johanna W Wilmink, J Hans De Vries and Marc G Besselink, on behalf of the Dutch Pancreatic Cancer Group