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J-domain proteins: from molecular mechanisms to diseases

J-domain proteins (JDPs) are known to drive the functional specificity of Hsp70 chaperone machines. Here we report on the latest findings presented at the third international JDP workshop held in 2025 in Gdansk, Poland. Investigators from many different disciplines, including structural biology, gen...

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Main Authors: Kirstein, Janine (Author) , Rosenzweig, Rina (Author) , De Los Rios, Paolo (Author) , Genevaux, Pierre (Author) , Adang, Charlotte (Author) , Andreasson, Claes (Author) , Balchin, David (Author) , Barducci, Alessandro (Author) , Blatch, Gregory L. (Author) , Braun, Janice E. A. (Author) , Brodsky, Jeffrey L. (Author) , Bukau, Bernd (Author) , Chapple, J. Paul (Author) , Cheetham, Michael E. (Author) , Craig, Elizabeth A. (Author) , Cyr, Douglas M. (Author) , Dementin, Sébastien (Author) , Faust, Ofrah (Author) , Genest, Olivier (Author) , Gestwicki, Jason E. (Author) , Goloubinoff, Pierre (Author) , Grabinska-Rogala, Aneta (Author) , Hammond, Colin M. (Author) , Inoue, Michio (Author) , Jiang, Yajun (Author) , Joachimiak, Lukasz A. (Author) , Kasai, Ayano (Author) , Klosowska, Agnieszka (Author) , Lee, Hyun O. (Author) , Liberek, Krzysztof (Author) , Musskopf, Maiara Kolbe (Author) , Linse, Sara (Author) , Mayer, Matthias P. (Author) , Mogk, Axel (Author) , Mokranjac, Dejana (Author) , Münch, Christian (Author) , Rebeaud, Mathieu E. (Author) , Rospert, Sabine (Author) , Sanagavarapu, Kalyani (Author) , Sahi, Chandan (Author) , Shalgi, Reut (Author) , Sutandy, F. X. Reymond (Author) , Tomiczek, Bartlomeij (Author) , Ushioda, Ryo (Author) , Weihl, Conrad C. (Author) , Ying, Zhang (Author) , Marszalek, Jaroslaw (Author) , Kampinga, Harm H. (Author)
Format: Article (Journal)
Language:English
Published: February 2026
In: Cell stress & chaperones
Year: 2026, Volume: 31, Issue: 1, Pages: 1-12
ISSN:1466-1268
DOI:10.1016/j.cstres.2025.100142
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.cstres.2025.100142
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1355814525000872
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Author Notes:Janine Kirstein, Rina Rosenzweig, Paolo De Los Rios, Pierre Genevaux, Charlotte Adang, Claes Andreasson, David Balchin, Alessandro Barducci, Gregory L. Blatch, Janice E. A. Braun, Jeffrey L. Brodsky, Bernd Bukau, J. Paul Chapple, Michael E. Cheetham, Elizabeth A. Craig, Douglas M. Cyr, Sébastien Dementin, Ofrah Faust, Olivier Genest, Jason E. Gestwicki, Pierre Goloubinoff, Aneta Grabinska-Rogala, Colin M. Hammond, Michio Inoue, Yajun Jiang, Lukasz A. Joachimiak, Ayano Kasai, Agnieszka Klosowska, Hyun O. Lee, Krzysztof Liberek, Maiara Kolbe Musskopf, Sara Linse, Matthias P. Mayer, Axel Mogk, Dejana Mokranjac, Christian Münch, Mathieu E. Rebeaud, Sabine Rospert, Kalyani Sanagavarapu, Chandan Sahi, Reut Shalgi, F. X. Reymond Sutandy, Bartlomeij Tomiczek, Ryo Ushioda, Conrad C. Weihl, Zhang Ying, Jaroslaw Marszalek, Harm H. Kampinga
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Summary:J-domain proteins (JDPs) are known to drive the functional specificity of Hsp70 chaperone machines. Here we report on the latest findings presented at the third international JDP workshop held in 2025 in Gdansk, Poland. Investigators from many different disciplines, including structural biology, genetics, chemical biology, translational research, computational sciences, and biophysics, took part in the meeting. This article includes short summaries of the seminars presented by many of the speakers, which provided exciting new insights into the chaperone-dependent and chaperone-independent functions of JDPs, some of which go beyond Hsp70-dependent functions. We also provide a revised classification of members of the (human) JDP family that emerged from open discussion at the meeting. This workshop continues to serve as the premier venue for discussions of JDP evolution, structure, function, and roles in health, aging, and disease.
Item Description:Gesehen am 01.04.2026
Physical Description:Online Resource
ISSN:1466-1268
DOI:10.1016/j.cstres.2025.100142

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