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Sex differences in efficacy and adverse events following bronchoscopic thermal vapour ablation for severe emphysema: results from a multinational real-world registry

Background: Bronchoscopic thermal vapour ablation (BTVA) is a treatment option for selected patients with severe emphysema, inducing lung volume reduction through a localised inflammatory response. This study investigated sex-specific differences in outcomes and safety after BTVA. Methods: Data from...

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Autori principali: Trudzinski, Franziska (Autore) , Kontogianni, Konstantina (Autore) , Valipour, Arschang (Autore) , Klemm, Theresa Antonia (Autore) , Eisenmann, Stephan (Autore) , Dittrich, A. Susanne (Autore) , Höger, Philipp (Autore) , Byczkowski, Teresa (Autore) , Feißt, Manuel (Autore) , Herth, Felix (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 11 March 2026
In: BMJ Open Respiratory Research
Year: 2026, Volume: 13, Fascicolo: 1, Pages: 1-9
ISSN:2052-4439
DOI:10.1136/bmjresp-2025-003932
Accesso online:Resolving-System, kostenfrei: https://doi.org/10.1136/bmjresp-2025-003932
Resolving-System, kostenfrei: https://doi.org/10.25673/123444
Testo
Note sull'autore:Franziska C. Trudzinski, Konstantina Kontogianni, Arschang Valipour, Theresa Klemm, Stephan Eisenmann, Joachim Ficker, Daniel Franzen, Wolfgang Gesierich, Christian Grah, Susanne Dittrich, Philipp Höger, Peter Hammerl, Martin Hetzel, Teresa Byczkowski, Manuel Feisst, Felix Herth, Kaid Darwiche
Descrizione
Riassunto:Background: Bronchoscopic thermal vapour ablation (BTVA) is a treatment option for selected patients with severe emphysema, inducing lung volume reduction through a localised inflammatory response. This study investigated sex-specific differences in outcomes and safety after BTVA. Methods: Data from the multicentre BTVA post-market registry (December 2018-July 2024) were retrospectively analysed. Sex-specific outcomes at 3, 6 and 12 months were compared, and the effect of sex on residual volume (RV%) was assessed using an adjusted mixed-effects model. Results: A total of 231 patients (105 women) were included. In women, significant improvements were observed in forced expiratory volume in 1 s at 3, 6 and 12 months (+60 mL, +70 mL, +20 mL), RV at 6 and 12 months (-0.38 L and -0.50 L), 6-Minute Walk Distance (6-MWD) at 3 and 6 months (+17.5 m and +23.5 m), and a consistent improvement in St. George’s Respiratory Questionnaire (SGRQ) at 3, 6 and 12 months (-9.3, -6.9, -9.1). In men, significant improvements were noted in RV at 3, 6 and 12 months (-0.32 L, -0.47 L, -0.32 L) and in SGRQ at 3 and 6 months (-4.8 and -3.7), but not at 12 months. An improvement in 6-MWD was not observed in men. Additionally, a significant time-by-sex interaction was observed for RV% (χ²=5.88, p=0.015), indicating distinct RV trajectories between the sexes. Conclusions: The results indicate that women experienced greater improvements in lung function and SGRQ scores after BTVA, which may be explained by differences in perception and reporting of functional benefits, as well as potential biological factors such as a stronger inflammatory response.
Descrizione del documento:Zuerst veröffentlicht: 11. März 2026
Descrizione fisica:Online Resource
ISSN:2052-4439
DOI:10.1136/bmjresp-2025-003932

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