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Effects of preoperative recombinant Interleukin 2-based immunomodulation on outcome after gastrointestinal cancer surgery: a systematic review and meta-analysis

Patients undergoing gastrointestinal cancer surgery are often immunocompromised and susceptible to infectious complications. Recombinant Interleukin 2 activates effector immune cells and stimulates the expansion of regulatory T-cells, making it a promising intervention for prevention of inflammatory...

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Bibliographic Details
Main Authors: Horcicka, Anna (Author) , Bewersdorf, Nicole (Author) , Kalkum, Eva (Author) , Zimmermann, Stefan (Author) , Grüßer, Linda (Author) , Dehne, Sarah (Author) , Weigand, Markus A. (Author) , Klotz, Rosa (Author) , Larmann, Jan (Author)
Format: Article (Journal)
Language:English
Published: 05 April 2026
In: British journal of cancer
Year: 2026, Volume: 134, Issue: 7, Pages: 1057-1065
ISSN:1532-1827
DOI:10.1038/s41416-025-03304-x
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1038/s41416-025-03304-x
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41416-025-03304-x
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Author Notes:A. Horcicka, N. Bewersdorf, E. Kalkum, S. Zimmermann, L. Grüßer, S. Dehne, M. A. Weigand, R. Klotz and J. Larmann
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Summary:Patients undergoing gastrointestinal cancer surgery are often immunocompromised and susceptible to infectious complications. Recombinant Interleukin 2 activates effector immune cells and stimulates the expansion of regulatory T-cells, making it a promising intervention for prevention of inflammatory complications.
Item Description:Online verfügbar: 17. Januar 2026
Gesehen am 09.04.2026
Physical Description:Online Resource
ISSN:1532-1827
DOI:10.1038/s41416-025-03304-x

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