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Allogeneic haematopoietic cell transplant in cutaneous T-cell lymphomas: recommendations from the EBMT PH&G Committee

This manuscript provides expert recommendations on the role of allogeneic haematopoietic cell transplantation (allo-HCT) for cutaneous T-cell lymphoma (CTCL), specifically mycosis fungoides (MF) and Sezary syndrome (SS). Critical aspects such as patient selection, timing, and bridging therapy are ad...

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Main Authors: Damaj, Gandhi (Author) , de Masson, Adèle (Author) , Dreger, Peter (Author) , Bazarbachi, Ali (Author) , Berning, Philipp (Author) , Duarte, Rafael F. (Author) , Fox, Christopher P. (Author) , Guenova, Emmanuella (Author) , Hermine, Olivier (Author) , Kyriakou, Charalampia (Author) , Tanase, Alina (Author) , Tournilhac, Olivier (Author) , Jurczak, Wojiech (Author) , Karsten, Imke E. (Author) , Quoc, Stéphanie Nguyen (Author) , Serroukh, Yasmina (Author) , Stella, Federico (Author) , Wulf, Gerald (Author) , Sureda, Anna (Author) , Papadavid, Evangelia (Author) , Ortiz-Romero, Pablo L. (Author) , Ruggeri, Annalisa (Author) , Sánchez-Ortega, Isabel (Author) , Scarisbrick, Julia J. (Author) , Yakoub-Agha, Ibrahim (Author) , Onida, Francesco (Author) , Schmitz, Norbert (Author)
Format: Article (Journal)
Language:English
Published: [27 January 2026]
In: Journal of the European Academy of Dermatology and Venereology
Year: 2026, Volume: 40, Issue: 2, Pages: 174-184
ISSN:1468-3083
DOI:10.1111/jdv.70042
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/jdv.70042
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.70042
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Author Notes:Gandhi Damaj, Adèle de Masson, Peter Dreger, Ali Bazarbachi, Philipp Berning, Rafael F. Duarte, Christopher P. Fox, Emmanuella Guenova, Olivier Hermine, Charalampia Kyriakou, Alina Tanase, Olivier Tournilhac, Wojiech Jurczak, Imke E. Karsten, Stéphanie Nguyen Quoc, Yasmina Serroukh, Federico Stella, Gerald Wulf, Anna Sureda, Evangelia Papadavid, Pablo L. Ortiz-Romero, Annalisa Ruggeri, Isabel Sánchez-Ortega, Julia J. Scarisbrick, Ibrahim Yakoub-Agha, Francesco Onida, Norbert Schmitz
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Summary:This manuscript provides expert recommendations on the role of allogeneic haematopoietic cell transplantation (allo-HCT) for cutaneous T-cell lymphoma (CTCL), specifically mycosis fungoides (MF) and Sezary syndrome (SS). Critical aspects such as patient selection, timing, and bridging therapy are addressed, as well as donor source, conditioning regimens and post-transplant management. These consensus guidelines are based on a thorough literature review and discussions among leading dermatologists and haematologists. These recommendations aim to harmonize clinical practice towards improving patient outcomes in these rare but aggressive lymphomas. It is of critical importance to consider allo-HCT early in the management of eligible patients with high-risk disease. Advanced stage, large-cell transformation, relapsed or refractory disease following systemic treatment, and N3-stage lymph node involvement are indicators that should trigger consultation with a transplant haematologist in parallel with a donor search. Early interaction between dermatologists and transplant haematologists is vital to avoiding delays, which can significantly impact post-transplant outcomes and survival.
Item Description:Gesehen am 09.04.2026
Physical Description:Online Resource
ISSN:1468-3083
DOI:10.1111/jdv.70042

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