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Allogeneic hematopoietic cell transplant in cutaneous T-cell lymphomas: recommendations from the EBMT PH&G committee

This manuscript provides expert recommendations on the role of allogeneic hematopoietic cell transplantation (allo-HCT) for cutaneous T-cell lymphoma (CTCL), specifically Mycosis Fungoides (MF) and Sezary Syndrome (SS). Critical aspects such as patient selection, timing, and bridging therapy are add...

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Main Authors: Damaj, Gandhi (Author) , de Masson, Adèle (Author) , Dreger, Peter (Author) , Bazarbachi, Ali (Author) , Berning, Philipp (Author) , Duarte, Rafael F. (Author) , Fox, Christopher P. (Author) , Guenova, Emmanuella (Author) , Hermine, Olivier (Author) , Kyriakou, Charalampia (Author) , Tanase, Alina (Author) , Tournilhac, Olivier (Author) , Jurczak, Wojiech (Author) , Karsten, Imke E. (Author) , Quoc, Stéphanie Nguyen (Author) , Serroukh, Yasmina (Author) , Stella, Federico (Author) , Wulf, Gerald (Author) , Sureda, Anna (Author) , Papadavid, Evangelia (Author) , Ortiz-Romero, Pablo L. (Author) , Ruggeri, Annalisa (Author) , Sánchez-Ortega, Isabel (Author) , Scarisbrick, Julia J. (Author) , Yakoub-Agha, Ibrahim (Author) , Onida, Francesco (Author) , Schmitz, Norbert (Author)
Format: Article (Journal)
Language:English
Published: 1 October 2025
In: Bone marrow transplantation
Year: 2025, Volume: 60, Issue: 12, Pages: 1565-1573
ISSN:1476-5365
DOI:10.1038/s41409-025-02696-x
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41409-025-02696-x
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41409-025-02696-x
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Author Notes:Gandhi Damaj, Adèle de Masson, Peter Dreger, Ali Bazarbachi, Philipp Berning, Rafael F. Duarte, Christopher P. Fox, Emmanuella Guenova, Olivier Hermine, Charalampia Kyriakou, Alina Tanase, Olivier Tournilhac, Wojiech Jurczak, Imke E. Karsten, Stéphanie Nguyen Quoc, Yasmina Serroukh, Federico Stella, Gerald Wulf, Anna Sureda, Evangelia Papadavid, Pablo L. Ortiz-Romero, Annalisa Ruggeri, Isabel Sánchez-Ortega, Julia J. Scarisbrick, Ibrahim Yakoub-Agha, Francesco Onida and Norbert Schmitz
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Summary:This manuscript provides expert recommendations on the role of allogeneic hematopoietic cell transplantation (allo-HCT) for cutaneous T-cell lymphoma (CTCL), specifically Mycosis Fungoides (MF) and Sezary Syndrome (SS). Critical aspects such as patient selection, timing, and bridging therapy are addressed, as well as donor source, conditioning regimens and post-transplant management. These consensus guidelines are based on a thorough literature review and discussions among leading dermatologists and hematologists. These recommendations aim to harmonise clinical practice towards improving patient outcomes in these rare but aggressive lymphomas. It is of critical importance to consider allo-HCT early in the management of eligible patients with high-risk disease. Advanced stage, large-cell transformation, relapsed or refractory disease following systemic treatment, and N3-stage lymph node involvement are indicators that should trigger consultation with a transplant hematologist in parallel with a donor search. Early interaction between dermatologists and transplant hematologists is vital to avoiding delays, which can significantly impact post-transplant outcomes and survival.
Item Description:Gesehen am 09.04.2026
Physical Description:Online Resource
ISSN:1476-5365
DOI:10.1038/s41409-025-02696-x

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