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The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution

Cell types are fundamental functional units that can be traced across the tree of life. Rapid advances in single-cell technologies, coupled with the phylogenetic expansion in genome sequencing, present opportunities for the molecular characterization of cells across a broad range of organisms. Despi...

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Autores principales: Sebé-Pedrós, Arnau (Autor) , Tanay, Amos (Autor) , Lawniczak, Mara K. N. (Autor) , Arendt, Detlev (Autor) , Aerts, Stein (Autor) , Archibald, John M. (Autor) , Arnone, Maria Ina (Autor) , Blaxter, Mark (Autor) , Cleves, Phillip (Autor) , Coelho, Susana M. (Autor) , Dias, Mafalda (Autor) , Dunn, Casey (Autor) , Elek, Anamaria (Autor) , Frazer, Jonathan (Autor) , Gabaldón, Toni (Autor) , Gillis, Jesse (Autor) , Grau-Bové, Xavier (Autor) , Guigó, Roderic (Autor) , Hobert, Oliver (Autor) , Huerta-Cepas, Jaime (Autor) , Irimia, Manuel (Autor) , Klein, Allon (Autor) , Lewin, Harris (Autor) , Lowe, Christopher J. (Autor) , Marlow, Heather (Autor) , Musser, Jacob M. (Autor) , Nagy, László G. (Autor) , Najle, Sebastián R. (Autor) , Pachter, Lior (Autor) , Paez, Sadye (Autor) , Papatheodorou, Irene (Autor) , Passalacqua, Michael J. (Autor) , Rajewsky, Nikolaus (Autor) , Rhee, Seung Y. (Autor) , Richards, Thomas A. (Autor) , Sauka-Spengler, Tatjana (Autor) , Saunders, Lauren (Autor) , Seuntjens, Eve (Autor) , Solana, Jordi (Autor) , Song, Yuyao (Autor) , Technau, Ulrich (Autor) , Wang, Bo (Autor)
Formato: Article (Journal)
Lenguaje:inglés
Publicado: 24 September 2025
In: Nature
Year: 2025, Volumen: 645, Número: 8082, Pages: 877-885
ISSN:1476-4687
DOI:10.1038/s41586-025-09312-4
Acceso en línea:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41586-025-09312-4
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41586-025-09312-4
Enlace del recurso
Notas de Autor:Arnau Sebé-Pedrós, Amos Tanay, Mara K. N. Lawniczak, Detlev Arendt, Stein Aerts, John Archibald, Maria Ina Arnone, Mark Blaxter, Phillip Cleves, Susana M. Coelho, Mafalda Dias, Casey Dunn, Anamaria Elek, Jonathan Frazer, Toni Gabaldón, Jesse Gillis, Xavier Grau-Bové, Roderic Guigó, Oliver Hobert, Jaime Huerta-Cepas, Manuel Irimia, Allon Klein, Harris Lewin, Christopher J. Lowe, Heather Marlow, Jacob M. Musser, László G. Nagy, Sebastián R. Najle, Lior Pachter, Sadye Paez, Irene Papatheodorou, Michael J. Passalacqua, Nikolaus Rajewsky, Seung Y. Rhee, Thomas A. Richards, Tatjana Sauka-Spengler, Lauren M. Saunders, Eve Seuntjens, Jordi Solana, Yuyao Song, Ulrich Technau, Bo Wang & Biodiversity Cell Atlas meeting participants
Descripción
Sumario:Cell types are fundamental functional units that can be traced across the tree of life. Rapid advances in single-cell technologies, coupled with the phylogenetic expansion in genome sequencing, present opportunities for the molecular characterization of cells across a broad range of organisms. Despite these developments, our understanding of eukaryotic cell diversity remains limited and we are far from decoding this diversity from genome sequences. Here we introduce the Biodiversity Cell Atlas initiative, which aims to create comprehensive single-cell molecular atlases across the eukaryotic tree of life. This community effort will be phylogenetically informed, rely on high-quality genomes and use shared standards to facilitate comparisons across species. The Biodiversity Cell Atlas aspires to deepen our understanding of the evolution and diversity of life at the cellular level, encompassing gene regulatory programs, differentiation trajectories, cell-type-specific molecular profiles and inter-organismal interactions.
Notas:Gesehen am 09.04.2026
Descripción Física:Online Resource
ISSN:1476-4687
DOI:10.1038/s41586-025-09312-4

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