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Cancer-related immune therapies: bidirectional implications from cardiotoxicity to emerging cardiovascular therapeutics : JACC CardioOncology State-of-the-Art Review

Immune-based therapies—including immune checkpoint inhibitors, bispecific T cell engagers, chimeric antigen receptor T cells, and tumor-infiltrating lymphocytes— not only have transformed cancer treatment, but also have introduced significant cardiovascular complications, posing new challenges for c...

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Bibliographic Details
Main Authors: Miteva, Kapka (Author) , Anker, Markus (Author) , Fechner, Henry (Author) , Lehmann, Lorenz (Author) , Linthout, Sophie Van (Author)
Format: Article (Journal) Review
Language:English
Published: August 2025
In: JACC: CardioOncology
Year: 2025, Volume: 7, Issue: 5, Pages: 523-537
ISSN:2666-0873
DOI:10.1016/j.jaccao.2025.06.008
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1016/j.jaccao.2025.06.008
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2666087325002510
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Author Notes:Kapka Miteva, Markus S. Anker, Henry Fechner, Lorenz Lehmann, Sophie Van Linthout
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Summary:Immune-based therapies—including immune checkpoint inhibitors, bispecific T cell engagers, chimeric antigen receptor T cells, and tumor-infiltrating lymphocytes— not only have transformed cancer treatment, but also have introduced significant cardiovascular complications, posing new challenges for cardio-oncology. Growing recognition of cardiovascular immune-related adverse events has spurred research into the immune-cardiovascular interface, particularly dysregulated signaling, T cell overactivation, and cytokine release. This review synthesizes recent insights into the role of immune checkpoints in cardiovascular disease, the mechanisms of immune checkpoint inhibitor- and T cell-induced cardiotoxicity, and the therapeutic potential of immune checkpoint modulation and chimeric antigen receptor T cell therapy in cardiovascular applications.
Item Description:Online veröffentlicht am: 19. August 2025
Gesehen am 13.04.2026
Physical Description:Online Resource
ISSN:2666-0873
DOI:10.1016/j.jaccao.2025.06.008

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