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Maternal depression with and without a history of childhood maltreatment and newborn white matter microstructure

Maternal depressive symptoms during pregnancy have consequences for offspring brain development, likely mediated via biological signals. However, gestational biological correlates of maternal depression may differ depending on childhood maltreatment (CM) history. We investigated the association of m...

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Hauptverfasser: Moog, Nora (Verfasst von) , Al-Ali, Khalid (Verfasst von) , Rasmussen, Jerod M. (Verfasst von) , Miller, Richard K. (Verfasst von) , Barrett, Emily S. (Verfasst von) , Graham, Alice M. (Verfasst von) , Fair, Damien A. (Verfasst von) , Tivarus, Madalina E. (Verfasst von) , Entringer, Sonja (Verfasst von) , Wadhwa, Pathik D. (Verfasst von) , Simhan, Hyagriv N. (Verfasst von) , O’Connor, Thomas G. (Verfasst von) , Styner, Martin (Verfasst von) , Buss, Claudia (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 24 February 2026
In: Psychological medicine
Year: 2026, Jahrgang: 56, Pages: 1-9
ISSN:1469-8978
DOI:10.1017/S0033291726103468
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1017/S0033291726103468
Verlag, lizenzpflichtig, Volltext: https://www.cambridge.org/core/journals/psychological-medicine/article/maternal-depression-with-and-without-a-history-of-childhood-maltreatment-and-newborn-white-matter-microstructure/784C103C3A3D0FFBE8A895546EF3C07B
Volltext
Verfasserangaben:Nora K. Moog, Khalid Al-Ali, Jerod M. Rasmussen, Richard K. Miller, Emily S. Barrett, Alice M. Graham, Damien A. Fair, Madalina E. Tivarus, Sonja Entringer, Pathik D. Wadhwa, Hyagriv N. Simhan, Thomas G. O’Connor, Martin Styner and Claudia Buss
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Zusammenfassung:Maternal depressive symptoms during pregnancy have consequences for offspring brain development, likely mediated via biological signals. However, gestational biological correlates of maternal depression may differ depending on childhood maltreatment (CM) history. We investigated the association of maternal depressive symptoms in pregnancy and CM history with newborn global white matter microstructure. In a sample of N = 90 mother-infant dyads from two cohorts, maternal depressive symptoms were assessed with the Edinburgh Postnatal Depression Scale. CM was assessed with the Childhood Trauma Questionnaire or the Adverse Childhood Experiences scale. Diffusion-weighted imaging was performed in the infants within 90 days of birth. Fiber profiles of fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) were determined, and a global mean for each metric was computed. In adjusted models, there was a significant interaction effect of maternal depression and CM on newborn global FA (β = −0.523, p = .029) and RD (β = 0.590, p = .014) but not AD (β = 0.367, p = .120). In infants of women with CM history, maternal depressive symptoms were correlated negatively with FA and positively with RD. In contrast, infants of women without CM exhibited the reverse pattern of associations between depressive symptoms and diffusion metrics. These findings suggest that the impact of prenatal exposures, such as maternal depressive symptoms, on offspring brain development may be conditional on the presence or absence of maltreatment history. These findings highlight the importance of assessing trauma history and monitoring psychosocial well-being during pregnancy.
Beschreibung:Veröffentlicht: 24. Februar 2026
Gesehen am 14.04.2026
Beschreibung:Online Resource
ISSN:1469-8978
DOI:10.1017/S0033291726103468

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