Targeting the sarcomere: myosin inhibitors as the revolutionary game changer in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) represents the most common inherited cardiac disease and a leading cause of heart failure, arrhythmias, and sudden cardiac death in young individuals. For decades, management of HCM has relied on symptom control with β-blockers, calcium channel blockers, disopyramid...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2026
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| In: |
Reviews in cardiovascular medicine
Year: 2026, Jahrgang: 27, Heft: 1, Pages: 1-9 |
| ISSN: | 2153-8174 |
| DOI: | 10.31083/RCM47341 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.31083/RCM47341 Verlag, kostenfrei, Volltext: https://www.imrpress.com/journal/RCM/27/1/10.31083/RCM47341 
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| Verfasserangaben: | Farbod Sedaghat-Hamedani, Elham Kayvanpour, Benjamin Meder |
| Zusammenfassung: | Hypertrophic cardiomyopathy (HCM) represents the most common inherited cardiac disease and a leading cause of heart failure, arrhythmias, and sudden cardiac death in young individuals. For decades, management of HCM has relied on symptom control with β-blockers, calcium channel blockers, disopyramide, or invasive septal reduction in advanced cases. The identification of pathogenic sarcomere variants and the recognition of hypercontractility as a central disease mechanism have paved the way for cardiac myosin inhibitors (CMIs), the first truly disease-specific pharmacological therapy for HCM. Indeed, CMIs represent a revolutionary therapeutic paradigm that redefines the standard of care by translating molecular discovery into clinical application. This review provides a guide to the mechanistic basis of sarcomere modulation, summarizes the clinical evidence for mavacamten and aficamten, and critically evaluates the evolving roles of both medications in obstructive and non-obstructive HCM. |
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| Beschreibung: | Online veröffentlicht: 22. Januar 2026 Gesehen am 15.04.2026 |
| Beschreibung: | Online Resource |
| ISSN: | 2153-8174 |
| DOI: | 10.31083/RCM47341 |