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Targeting the sarcomere: myosin inhibitors as the revolutionary game changer in hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) represents the most common inherited cardiac disease and a leading cause of heart failure, arrhythmias, and sudden cardiac death in young individuals. For decades, management of HCM has relied on symptom control with β-blockers, calcium channel blockers, disopyramid...

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Bibliographic Details
Main Authors: Sedaghat-Hamedani, Farbod (Author) , Kayvanpour, Elham (Author) , Meder, Benjamin (Author)
Format: Article (Journal)
Language:English
Published: 2026
In: Reviews in cardiovascular medicine
Year: 2026, Volume: 27, Issue: 1, Pages: 1-9
ISSN:2153-8174
DOI:10.31083/RCM47341
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.31083/RCM47341
Verlag, kostenfrei, Volltext: https://www.imrpress.com/journal/RCM/27/1/10.31083/RCM47341
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Author Notes:Farbod Sedaghat-Hamedani, Elham Kayvanpour, Benjamin Meder
Description
Summary:Hypertrophic cardiomyopathy (HCM) represents the most common inherited cardiac disease and a leading cause of heart failure, arrhythmias, and sudden cardiac death in young individuals. For decades, management of HCM has relied on symptom control with β-blockers, calcium channel blockers, disopyramide, or invasive septal reduction in advanced cases. The identification of pathogenic sarcomere variants and the recognition of hypercontractility as a central disease mechanism have paved the way for cardiac myosin inhibitors (CMIs), the first truly disease-specific pharmacological therapy for HCM. Indeed, CMIs represent a revolutionary therapeutic paradigm that redefines the standard of care by translating molecular discovery into clinical application. This review provides a guide to the mechanistic basis of sarcomere modulation, summarizes the clinical evidence for mavacamten and aficamten, and critically evaluates the evolving roles of both medications in obstructive and non-obstructive HCM.
Item Description:Online veröffentlicht: 22. Januar 2026
Gesehen am 15.04.2026
Physical Description:Online Resource
ISSN:2153-8174
DOI:10.31083/RCM47341

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