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Prognostic potential of circulatory miR-19a-3p, miR-19b-3p, and miR-329-3p for future hypertension diagnosis

MicroRNAs have been suggested as essential hypertension biomarkers, but evidence remains inconclusive due to limited high-throughput studies in population cohorts. - We analyzed data from the Young Finns Study (YFS) from 2011 and 2018-2020 to assess cross-sectional and prospective associations betwe...

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Main Authors: Kostiniuk, Daria (Author) , Blankenstein, Antti (Author) , Rajić, Sonja (Author) , Ciantar, Joanna (Author) , Mononen, Nina (Author) , Lyytikäinen, Leo-Pekka (Author) , Seppälä, Ilkka (Author) , Mishra, Pashupati P. (Author) , Juonala, Markus (Author) , Waldenberger, Melanie (Author) , Elovainio, Marko (Author) , Oksala, Niku (Author) , Kähönen, Mika (Author) , Hutri, Nina (Author) , Raitakari, Olli (Author) , Kleber, Marcus E. (Author) , März, Winfried (Author) , Lehtimäki, Terho (Author) , Marttila, Saara (Author) , Raitoharju, Emma (Author)
Format: Article (Journal)
Language:English
Published: May 2026
In: Journal of hypertension
Year: 2026, Volume: 44, Issue: 5, Pages: 811-822
ISSN:1473-5598
DOI:10.1097/HJH.0000000000004272
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1097/HJH.0000000000004272
Verlag, kostenfrei, Volltext: https://journals.lww.com/jhypertension/fulltext/2026/05000/prognostic_potential_of_circulatory_mir_19a_3p,.12.aspx
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Author Notes:Daria Kostiniuk, Antti Blankenstein, Sonja Rajić, Joanna Ciantar, Nina Mononen, Leo-Pekka Lyytikäinen, Ilkka Seppälä, Pashupati P. Mishra, Markus Juonala, Melanie Waldenberger, Marko Elovainio, Niku Oksala, Mika Kähönen, Nina Hutri, Olli Raitakari, Marcus E. Kleber, Winfried März, Terho Lehtimäki, Saara Marttila and Emma Raitoharju
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Summary:MicroRNAs have been suggested as essential hypertension biomarkers, but evidence remains inconclusive due to limited high-throughput studies in population cohorts. - We analyzed data from the Young Finns Study (YFS) from 2011 and 2018-2020 to assess cross-sectional and prospective associations between circulatory microRNAs, blood pressure (BP), and hypertension. Hypertension risk prediction potential was assessed using nested logistic and Weibull survival models; model performance was evaluated with likelihood ratio (LR) test and c-statistic. All models were adjusted with relevant risk factors. - In 2011, whole blood microRNAs were profiled for 871 individuals (83 with hypertension); in 2018-2020, 760 were re-examined, with 67 newly diagnosed. Cross-sectionally, 16 miRNAs correlated with BP (Spearman, PFDR < 0.05); miR-122-5p (fold change = 1.33) and miR-144-5p (fold change = -1.10) differentiated hypertensive individuals (U test, PFDR < 0.05). Associations persisted in adjusted regression models and some replicated in LURIC (n = 999) and YFS serum data (n = 126). Prospectively, miR-19a-3p [odds ratio (OR) = 1.51, 95% confidence interval (95% CI): 1.14-2.18], miR-19b-3p (OR = 1.50, 95% CI:1.11-2.04), and miR-329-3p (OR = 0.58, 95% CI: 0.39-0.74) levels prognosed hypertension incident. miR-329-3p improved model fit (LR test, P = 2.85×10-4) and discrimination (c-statistic = 0.849, Δ = 0.026). miR-19b-3p predicted time to onset (hazard ratio = 2.13, 95% CI: 1.38-4.45), improving model fit (LR test, P = 0.0012) and time-dependent discrimination at 7 and 8-year horizons. - Our findings highlight both novel and previously reported miRNAs associating with BP and hypertension and suggest that miR-329-3p, miR-19a-3p, and miR-19b-3p as promising candidates for further investigation in hypertension risk prediction.
Item Description:Gesehen am 16.04.2026
Physical Description:Online Resource
ISSN:1473-5598
DOI:10.1097/HJH.0000000000004272

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