A cost-effectiveness analysis of novel stool processing methods for diagnosis of tuberculosis in children under 5 years of age in Uganda

Stool-based molecular assays for childhood tuberculosis (TB) diagnosis have shown promise as an alternative to respiratory sample testing. While implementation is underway, evidence on cost-effectiveness is needed. Therefore, we aimed to evaluate the costs of stool testing with Xpert Ultra and model...

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Main Authors: Gaeddert, Mary (Author) , Jaganath, Devan (Author) , Nguyen, Hoa Thi (Author) , Civan, Abdülkadir (Author) , Nabeta, Pamela (Author) , Trollip, Andre (Author) , Castro, Robert (Author) , Nakabuye, Mariam (Author) , Nsereko, Moses (Author) , Aben, Ernest (Author) , Wambi, Peter (Author) , Marcy, Olivier (Author) , Wobudeya, Eric (Author) , Cattamanchi, Adithya (Author) , Andama, Alfred (Author) , De Allegri, Manuela (Author) , Denkinger, Claudia M. (Author)
Format: Article (Journal)
Language:English
Published: 13 October 2025
In: BMC health services research
Year: 2025, Volume: 25, Pages: 1-11
ISSN:1472-6963
DOI:10.1186/s12913-025-13546-3
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12913-025-13546-3
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Author Notes:Mary Gaeddert, Devan Jaganath, Hoa Thi Nguyen, Abdulkadir Civan, Pamela Nabeta, Andre Trollip, Robert Castro, Mariam Nakabuye, Moses Nsereko, Ernest Aben, Peter Wambi, Olivier Marcy, Eric Wobudeya, Adithya Cattamanchi, Alfred Andama, Manuela De Allegri and Claudia M. Denkinger
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Summary:Stool-based molecular assays for childhood tuberculosis (TB) diagnosis have shown promise as an alternative to respiratory sample testing. While implementation is underway, evidence on cost-effectiveness is needed. Therefore, we aimed to evaluate the costs of stool testing with Xpert Ultra and model the cost-effectiveness of implementation scenarios at lower levels of care.
Item Description:Gesehen am 20.04.2026
Physical Description:Online Resource
ISSN:1472-6963
DOI:10.1186/s12913-025-13546-3