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Tumour-associated macrophage infiltration differs in meningioma genotypes, and is important in tumour dynamics

Meningiomas are the most common primary intracranial tumours, with clinical behaviours ranging from benign to highly aggressive forms. The World Health Organisation classifies meningiomas into various grades, guiding prognosis and treatment. While surgery is effective for low-grade meningiomas, cert...

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Hauptverfasser: Zhang, Ting (Verfasst von) , Adams, Claire L. (Verfasst von) , Fejer, Gyorgy (Verfasst von) , Ercolano, Emanuela (Verfasst von) , Cutajar, Jonathan (Verfasst von) , Na, Juri (Verfasst von) , Sahm, Felix (Verfasst von) , Hanemann, C. Oliver (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 27 May 2025
In: Journal of experimental & clinical cancer research
Year: 2025, Jahrgang: 44, Pages: 1-18
ISSN:1756-9966
DOI:10.1186/s13046-025-03419-2
Online-Zugang:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s13046-025-03419-2
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1186/s13046-025-03419-2
Volltext
Verfasserangaben:Ting Zhang, Claire L. Adams, Gyorgy Fejer, Emanuela Ercolano, Jonathan Cutajar, Juri Na, Felix Sahm and C. Oliver Hanemann
Beschreibung
Zusammenfassung:Meningiomas are the most common primary intracranial tumours, with clinical behaviours ranging from benign to highly aggressive forms. The World Health Organisation classifies meningiomas into various grades, guiding prognosis and treatment. While surgery is effective for low-grade meningiomas, certain grade 1 tumours, as well as grade 2, 3, and recurrent cases are more aggressive and require new therapeutic approaches. Immunotherapy shows promise, with early-stage clinical trials demonstrating encouraging results. The tumour microenvironment (TME), particularly tumour-associated macrophages (TAMs), plays a pivotal role in tumour progression. TAMs influence tumour growth, metastasis, and immune evasion. However, their role in meningiomas, especially in relation to genomic mutations, remains poorly understood. Understanding how genetic alterations affect the TME is critical for developing targeted immunotherapies.
Beschreibung:Gesehen am 21.04.2026
Beschreibung:Online Resource
ISSN:1756-9966
DOI:10.1186/s13046-025-03419-2

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