Genetic testing in chronic kidney disease of uneXplained cause (CKDx): clinical insights and evolving diagnostic paradigms
Chronic kidney disease (CKD) represents a significant global health burden, with diverse etiologies and often complex clinical presentations. Among these, a notable subset of CKD patients present without a clear underlying cause despite extensive diagnostic evaluation. For this subgroup, the term CK...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
18. Februar 2026
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| In: |
Medizinische Genetik
Year: 2026, Volume: 38, Issue: 1, Pages: 21-28 |
| ISSN: | 1863-5490 |
| DOI: | 10.1515/medgen-2025-2046 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1515/medgen-2025-2046 Verlag, kostenfrei, Volltext: https://www.degruyterbrill.com/document/doi/10.1515/medgen-2025-2046/html 
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| Author Notes: | Jan Halbritter, Matias Simons |
| Summary: | Chronic kidney disease (CKD) represents a significant global health burden, with diverse etiologies and often complex clinical presentations. Among these, a notable subset of CKD patients present without a clear underlying cause despite extensive diagnostic evaluation. For this subgroup, the term CKDx - chronic kidney disease of unexplained cause, has recently been proposed. A major element of the diagnostic workup of CKDx is genetic testing, for which the methodology has greatly improved in the last years. |
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| Item Description: | Veröffentlicht: 18. Februar 2026 Gesehen am 22.04.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1863-5490 |
| DOI: | 10.1515/medgen-2025-2046 |