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Rapastinel alleviates the neurotoxic effect induced by NMDA receptor blockade in the early postnatal mouse brain

Rapastinel is a novel psychoactive substance that acts as an N-methyl-D-aspartate-receptor (NMDAR) agonist and triggers antidepressant- and antipsychotic-like effects in animal models. However, it is unknown if rapastinel possesses a better side-effect profile than fast-acting glutamatergic antidepr...

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Main Authors: Vasilescu, Andrei-Nicolae (Author) , Mallien, Anne Stephanie (Author) , Pfeiffer, Natascha (Author) , Lang, Undine (Author) , Gass, Peter (Author) , Inta, Dragos (Author)
Format: Article (Journal)
Language:English
Published: December 2021
In: European archives of psychiatry and clinical neuroscience
Year: 2021, Volume: 271, Issue: 8, Pages: 1587-1591
ISSN:1433-8491
DOI:10.1007/s00406-020-01180-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00406-020-01180-5
Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s00406-020-01180-5
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Author Notes:Andrei-Nicolae Vasilescu, Anne Mallien, Natascha Pfeiffer, Undine E. Lang, Peter Gass, Dragos Inta
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Summary:Rapastinel is a novel psychoactive substance that acts as an N-methyl-D-aspartate-receptor (NMDAR) agonist and triggers antidepressant- and antipsychotic-like effects in animal models. However, it is unknown if rapastinel possesses a better side-effect profile than fast-acting glutamatergic antidepressants, like ketamine, which trigger neurotoxicity in the perinatal rodent cortex and protracted schizophrenia-like alterations. Here we found a remarkable neuroprotective effect of rapastinel against apoptosis induced by the NMDAR antagonist MK-801 in comparison to that elicited by clozapine and the mGlu2/3 agonist LY354740. These results suggest the potential therapeutic/prophylactic effect of rapastinel in ameliorating deleterious effects induced by NMDAR blockade during neurodevelopment.
Item Description:Online publiziert: 13. August 2020
Gesehen am 23.04.2026
Physical Description:Online Resource
ISSN:1433-8491
DOI:10.1007/s00406-020-01180-5

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