Buchumschlag

Rapastinel alleviates the neurotoxic effect induced by NMDA receptor blockade in the early postnatal mouse brain

Rapastinel is a novel psychoactive substance that acts as an N-methyl-D-aspartate-receptor (NMDAR) agonist and triggers antidepressant- and antipsychotic-like effects in animal models. However, it is unknown if rapastinel possesses a better side-effect profile than fast-acting glutamatergic antidepr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Vasilescu, Andrei-Nicolae (Verfasst von) , Mallien, Anne Stephanie (Verfasst von) , Pfeiffer, Natascha (Verfasst von) , Lang, Undine (Verfasst von) , Gass, Peter (Verfasst von) , Inta, Dragos (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: December 2021
In: European archives of psychiatry and clinical neuroscience
Year: 2021, Jahrgang: 271, Heft: 8, Pages: 1587-1591
ISSN:1433-8491
DOI:10.1007/s00406-020-01180-5
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00406-020-01180-5
Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s00406-020-01180-5
Volltext
Verfasserangaben:Andrei-Nicolae Vasilescu, Anne Mallien, Natascha Pfeiffer, Undine E. Lang, Peter Gass, Dragos Inta
Beschreibung
Zusammenfassung:Rapastinel is a novel psychoactive substance that acts as an N-methyl-D-aspartate-receptor (NMDAR) agonist and triggers antidepressant- and antipsychotic-like effects in animal models. However, it is unknown if rapastinel possesses a better side-effect profile than fast-acting glutamatergic antidepressants, like ketamine, which trigger neurotoxicity in the perinatal rodent cortex and protracted schizophrenia-like alterations. Here we found a remarkable neuroprotective effect of rapastinel against apoptosis induced by the NMDAR antagonist MK-801 in comparison to that elicited by clozapine and the mGlu2/3 agonist LY354740. These results suggest the potential therapeutic/prophylactic effect of rapastinel in ameliorating deleterious effects induced by NMDAR blockade during neurodevelopment.
Beschreibung:Online publiziert: 13. August 2020
Gesehen am 23.04.2026
Beschreibung:Online Resource
ISSN:1433-8491
DOI:10.1007/s00406-020-01180-5

Ähnliche Einträge