Corticothalamic layer 6 controls cortical activity and thalamic firing mode in a bidirectional manner
Corticothalamic layer 6 modulates information flow between cortical and thalamic circuits. Previous research reported contrasting inhibitory or excitatory effects of corticothalamic layer 6 on cortical dynamics, potentially reflecting technological discrepancies or physiological differences in corti...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 2026
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| In: |
Cerebral cortex
Year: 2026, Jahrgang: 36, Heft: 3, Pages: 1-11 |
| ISSN: | 1460-2199 |
| DOI: | 10.1093/cercor/bhag029 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1093/cercor/bhag029
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| Verfasserangaben: | Ross Folkard, Emilio Ulises Isaías-Camacho and Alexander Groh |
| Zusammenfassung: | Corticothalamic layer 6 modulates information flow between cortical and thalamic circuits. Previous research reported contrasting inhibitory or excitatory effects of corticothalamic layer 6 on cortical dynamics, potentially reflecting technological discrepancies or physiological differences in corticothalamic layer 6 function. To resolve these discrepancies, we combined translaminar, multi-channel in vivo electrophysiology in the primary somatosensory cortex of anesthetized mice with optogenetic stimulation across a range of stimulation regimes to manipulate firing rate and spiking statistics of corticothalamic layer 6. Increasing corticothalamic layer 6 firing rates exerted a transition from inhibition to excitation across cortical layers. Furthermore, corticothalamic layer 6 activity imparted population synchrony onto distinct cortical subpopulations, independent of changes in overall corticothalamic layer 6 activity. In the thalamus, corticothalamic layer 6 modulated thalamic bursting in a bidirectional manner, dependent on optogenetic stimulation frequency. These results demonstrate that corticothalamic layer 6 in primary somatosensory cortex can bidirectionally modulate both cortical firing and thalamic firing mode, elucidating a more nuanced function of somatosensory corticothalamic layer 6 in thalamic and cortical signaling than previously recognized. |
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| Beschreibung: | Veröffentlicht: 24. März 2026 Gesehen am 24.04.2026 |
| Beschreibung: | Online Resource |
| ISSN: | 1460-2199 |
| DOI: | 10.1093/cercor/bhag029 |