Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes
Identifying significantly mutated genes in tumors aids in understanding disease etiology and survival and may aid in the discovery of new drug targets. We aimed to detect and characterize mutated genes from a large, well-characterized group of colorectal cancers.
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
18 December 2025
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| In: |
BMC cancer
Year: 2025, Jahrgang: 26, Pages: 1-14 |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/s12885-025-15440-x |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12885-025-15440-x |
| Verfasserangaben: | Tabitha A. Harrison, Syed H. Zaidi, Hang Yin, Robert S. Steinfelder, Conghui Qu, Elom K. Aglago, Sonja I. Berndt, Lisa A. Boardman, Hermann Brenner, Daniel D. Buchanan, Peter T. Campbell, Yin Cao, Andrew T. Chan, Stephen J. Chanock, Kimberly F. Doheny, David A. Drew, Jane C. Figueiredo, Amy J. French, Steven Gallinger, Peter Georgeson, Marios Giannakis, Ellen L. Goode, Stephen B. Gruber, Andrea Gsur, Marc J. Gunter, Sophia Harlid, Michael Hoffmeister, Wen-Yi Huang, Meredith AJ. Hullar, Jeroen R. Huyghe, Mark A. Jenkins, Yi Lin, Victor Moreno, Neil Murphy, Polly A. Newcomb, Christina C. Newton, Jonathan A. Nowak, Mireia Obón-Santacana, Shuji Ogino, Tameka Shelford, Mingyang Song, Claire E. Thomas, Amanda E. Toland, Tomotaka Ugai, Caroline Y. Um, Bethany Van Guelpen, Quang M. Trinh, Wei Sun, Thomas J. Hudson, Li Hsu, Ulrike Peters and Amanda I. Phipps |
| Zusammenfassung: | Identifying significantly mutated genes in tumors aids in understanding disease etiology and survival and may aid in the discovery of new drug targets. We aimed to detect and characterize mutated genes from a large, well-characterized group of colorectal cancers. |
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| Beschreibung: | Gesehen am 27.04.2026 |
| Beschreibung: | Online Resource |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/s12885-025-15440-x |